کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
7628313 | 1645353 | 2016 | 13 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Development of a simple, rapid, and robust liquid chromatographic method for the simultaneous determination of sulfalene, sulfadoxine, and pyrimethamine in tablets
ترجمه فارسی عنوان
توسعه یک روش کروماتوگرافی مایع ساده، سریع و قوی برای تعیین همزمان سولفالن، سولفادوکسی و پری متیامین در قرص
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کلمات کلیدی
APItfdAUSPBfArMRP-HPLCLOQRSDrelative standard deviation - انحراف استاندارد نسبیUnited States pharmacopoeia - ایالات متحده pharmacopoeiaFixed dose combination - ترکیب دوز ثابتLOD یا Limit of detection - حد تشخیصMalaria - مالاریاlimit of quantification - محدودیت اندازه گیریlimit of detection - محدودیت تشخیصICH - منActive Pharmaceutical Ingredient - مواد اولیه دارویی فعالDeveloping countries - کشورهای در حال توسعهquality control - کنترل کیفیت
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آنالیزی یا شیمی تجزیه
چکیده انگلیسی
A simple, cost effective, accurate, and precise RP-HPLC method was developed for the simultaneous determination of sulfalene and sulfadoxine in fixed dose dual combinations with pyrimethamine together with their related substances. Proprietary products containing these combinations are often being prescribed in malaria endemic countries. Quantification of the active compounds and impurity profiling was achieved using two standard C18 columns with a mobile phase being composed of 60% (v/v) of a 0.05Â M KH2PO4 buffer solution (pHÂ =Â 2.6) and 40% (v/v) of methanol, applying an isocratic elution mode and a detection wavelength of 215Â nm. The method allows a quick quantitative determination of sulfadoxine and sulfalene and the separation of the respective impurities within a total runtime of approximately 15Â min and was validated with respect to specificity, linearity, precision, accuracy, limits of detection and quantification, robustness, and stability of the standard and sample solutions. The method is simpler than the corresponding method described in the International Pharmacopoeia and the United States Pharmacopoeia in terms of being easy to apply, being less time consuming, and utilizing reagents and chemicals which are cost efficient.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical and Biomedical Analysis - Volume 129, 10 September 2016, Pages 558-570
Journal: Journal of Pharmaceutical and Biomedical Analysis - Volume 129, 10 September 2016, Pages 558-570
نویسندگان
Yonah H. Mwalwisi, Ludwig Hoellein, Eliangiringa Kaale, Ulrike Holzgrabe,