کد مقاله کد نشریه سال انتشار مقاله انگلیسی ترجمه فارسی نسخه تمام متن
7006746 1455159 2016 49 صفحه PDF سفارش دهید دانلود رایگان
عنوان انگلیسی مقاله ISI
Incorporating potential environmental impact from water for injection in environmental assessment of monoclonal antibody production
ترجمه فارسی عنوان
شامل تاثیر احتمالی زیست محیطی از آب برای تزریق در ارزیابی محیط زیست از تولید آنتی بادی منوکلونال
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه مهندسی شیمی تصفیه و جداسازی
چکیده انگلیسی
Biopharmaceutical industries consistently demand water for injection (WFI) in their production. WFI production requires large amount of energy that may leave environmental footprint. However, its potential environmental impact (PEI) is typically not included in environmental assessment. This paper aims to present how WFI generation would contribute to environmental pollution. It was assumed that WFI was generated in multiple effect distillation (MED), where utility steam is used as heating media. Utility steam is generated in a steam boiler, where several gas pollutants are produced as by-product. The PEI of these pollutants was estimated based on a modified waste reduction (WAR) algorithm. For data generation, MED was simulated in SuperPro Designer®. To demonstrate the way to include WFI into an environmental assessment, a hypothetical monoclonal antibody process was used as a case-study. From the case-study, it can be seen that WFI generation contributed the most to energy consumption and to the total PEI value. Therefore, it is important to include PEI from WFI in the environmental assessment for more accurate results, particularly when comparing several process designs as the results may influence decision-making.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Chemical Engineering Research and Design - Volume 109, May 2016, Pages 430-442
نویسندگان
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