Keywords: BAC; Blood alcohol content; B-BAES; Brief Biphasic Alcohol Effects Scale; CO; Carbon monoxide; DDS; dependent daily smokers; FTCD; Fagerström test for Cigarette Dependence; NNS; nondependent nondaily smokers; NRT; nicotine replacement therapy; QSU-Brief;
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Genetic polymorphisms of the 5HT receptors are not related with depression in temporal lobe epilepsy caused by hippocampal sclerosis
Keywords: IBGE; Brazilian Institute of Geography and Statistics; ILAE; International League Against Epilepsy; MRI; magnetic resonance imaging; MDD; major depressive disorder; DSM-IV-TR; Multiaxial Diagnostic and Statistical Manual; PCR; polynucleotide chain reactio
The impacts of nineteen mutations on the enzymatic activity of USP26
Keywords: USP; ubiquitin-specific protease; DUBs; deubiquitinating enzymes; USP26; ubiquitin-specific protease 26; GST-USP26; glutathione S-transferase (GST) fusion protein; Ub-Met-β-gal; glutathione ubiquitin-β-galactosidase; Ubiquitin-proteasome protease (USP26
Novel highly selective inhibitors of ubiquitin specific protease 30 (USP30) accelerate mitophagy
Keywords: USP; ubiquitin specific peptidase; DUB; deubiquitinase; biotin-UbVME; biotin-ubiquitin-vinylmethyl ester; BrdU; bromodeoxyuridine; Mitophagy; Deubiquitinase inhibitor; Parkin; USP30;
A comparison of in vitro cytotoxicity assays in medical device regulatory studies
Keywords: Cytotoxicity; Medical device; Qualitative and quantitative; MTT/XTT; tetrazolium; NR; neutral red; CFA; colony formation assay; MEM; minimal essential medium; HTS; high throughput screening; MHLW; Japan Ministry of Health Labour and Welfare; USP; United S
Challenges for Pacific Small Island Developing States in achieving their Nationally Determined Contributions (NDC)
Keywords: ADB; Asian Development Bank; CH4; Methane; CO2; Carbon Dioxide; COP21; United Nations Climate Change Conference, November 2015, Paris, France; CROP; Council of Regional Organisations; EEDI; Expected Electricity Demand Increase; FF; Fossil Fuel (plants); F
Intrinsically disordered N-terminal domain of the Helicoverpa armigera Ultraspiracle stabilizes the dimeric form via a scorpion-like structure
Keywords: NRs; nuclear receptors; NTD; N-terminal domain; DBD; DNA-binding domain; LBD; ligand-binding domain; EcR; ecdysone receptor; Usp; Ultraspiracle; IDR; intrinsically disordered region; HaUsp; Usp from Helicoverpa armigera; HaUsp_ÎNTD; Usp from Helicoverpa
938RHRK941 is responsible for Ubiquitin specific protease 48 nuclear translocation which can stabilize NF-κB (p65) in the nucleus
Keywords: USP48; ubiquitin-specific protease 48; synUSP; synaptic ubiquitin-specific protease; USP; ubiquitin-specific proteases; p65; RelA; NF-κB1; p50 and its precursor p100; NF-κB2; p52 and its precursor p105; Ubiquitin-specific protease 48; NF-κB (p65); Tran
St John's wort (Hypericum perforatum) products - an assessment of their authenticity and quality
Keywords: Quality control; Value chains,; Traditional Herbal Registration (THR); Avicularin/guaijaverin; St John's wort; Hypericum perforatum; ADC; automatic developing chamber; AV; avicularin; BRM; botanical reference material; DCHA; dicyclohexylamine; DCM; dichlo
Endocrine and physiological regulation of neutral fat storage in Drosophila
Keywords: Lipid metabolism; Drosophila; Obesity; Insulin; TOR; Ecdysone; AGPAT; acylglycerol-3-phosphate acyltransferase; AKH; adipokinetic hormone; BMM; Brummer; CC; corpora cardiac; DAG; diacylglycerol; Dilp; Drosophila insulin-like peptide; DGAT; diacylglycerol
Change of the 5α/5β ratio of urinary steroid metabolites in benign prostatic hyperplasia patients treated with dutasteride
Keywords: USP; urinary steroid profiling; GC/MS; gas chromatography/mass spectrometry; BPH; benign prostatic hyperplasia; DHT; dihydrotestosterone; DUT; dutasteride; 5AR; 5α-reductase; 5ARI; 5α-reductase inhibitor; FIN; finasteride; IPSS; International Prostate S
Microencapsulation of lutein by spray-drying: Characterization and stability analyses to promote its use as a functional ingredient
Keywords: RH; relative humidity; AMD; age-related macular degeneration; SFE; supercritical fluid extraction; USP; United States Pharmacopeia; YE; yield of encapsulation; EE; encapsulation efficiency; HPLC; high-performance liquid chromatography; DAD; diode-array de
Characterization of the Ubiquitin Specific Protease (USP) family members in the fast and slow muscle fibers from Chinese perch (Siniperca chuatsi)
Keywords: USP; Ubiquitin Specific Protease; MAFbx; Muscle Atrophy F-Box Protein; MurF1; muscle RING finger 1; GO; gene ontology; KEGG; Kyoto Encyclopedia of Genes and Genomes; CYLD; CYLD Lysine 63 Deubiquitinase; Skeletal muscle; Ubiquitin Specific Protease; Muscle
Mechanistic Physiologically Based Pharmacokinetic Modeling of the Dissolution and Food Effect of a Biopharmaceutics Classification System IV Compound-The Venetoclax Story
Keywords: amorphous; absorption, distribution, metabolism, and excretion (ADME); bioavailability; food effect; physiologically based pharmacokinetic modeling; clinical pharmacokinetics; intestinal absorption; passive diffusion/transport; drug interaction; ASD; Amor
Preparation of a crystalline salt of indomethacin and tromethamine by hot melt extrusion technology
Keywords: Crystalline salt; Indomethacin; Tromethamine; Hot melt extrusion; Solution-phase NMR; hot melt extrusion; HME; solvent evaporation; SE; differential scanning calorimetry; DSC; hot-stage polarized light microscopy; HSPLM; Fourier transform infrared spectro
Quality specifications for articles of botanical origin from the United States Pharmacopeia
Keywords: United States Pharmacopeia; Botanical dietary supplements; Herbal medicines; High-performance liquid chromatography identification; High-performance thin-layer chromatography identification; Specifications for botanicals; DI; dietary ingredients; DS; diet
Urine metabolomics shows an induction of fatty acids metabolism in healthy adult volunteers after supplementation with green coffee (Coffea robusta L.) bean extract
Keywords: Green coffee; Metabolomics; Urine; Caffeoyl quinic acid; GCBE; Green coffee bean extract; CGA; Chlorogenic acid; PPAR-α; Peroxisome proliferator-activated receptors α; 8-OHdG; 8-Hydroxydeoxyguanosine; LC; Liquid Chromatography; MS; Mass Spectrometry; UP
In vitro models for immunogenicity prediction of therapeutic proteins
Keywords: Therapeutic protein; Immunogenicity assessment; In vitro model; Subcutaneous injection; Injection site reactions; ADAs; antidrug antibodies; ALN; artificial lymph node; APCs; antigen presenting cells; ASCs; adipose-derived stem/stromal cells; DCs; dendrit
Dry powder inhalers: An overview of the in vitro dissolution methodologies and their correlation with the biopharmaceutical aspects of the drug products
Keywords: Pulmonary delivery; Dry powder inhalation; Solubility; Dissolution methods; Biopharmaceutical classification; API; Active pharmaceutical ingredient; ACI; Andersen cascade impactor; ALF; alveolar lung fluid; BCS; Biopharmaceutics Classification System; iBC
An overview of experimental designs in HPLC method development and validation
Keywords: 2D-HPLC; two-dimensional HPLC; AEMC; anion-exchange membrane chromatography; ANOVA; analysis of variance; BBD; Box-Behnken design; CC; chaotropic chromatography; CCD; central composite Design; CEX-HPLC; cation exchange high performance liquid chromatograp
Use of biorelevant dissolution and PBPK modeling to predict oral drug absorption
Keywords: Biorelevant dissolution; Weak base; PBPK modeling; BCS class II; pH dependent solubility; ACAT; advanced compartmental absorption and transit model; ADAM; advanced dissolution, absorption and metabolism model; API; active pharmaceutical ingredient; ASD;
Nsp3 of coronaviruses: Structures and functions of a large multi-domain protein
Keywords: Ubiquitin-like domain; Papain-like protease; Macrodomain; Nucleic-acid binding domain; Innate immunity; Structural biology; 3CLpro; 3C-like protease; 3Ecto; Nsp3 ectodomain; ADPr; ADP-ribose; ADRP; ADP-ribose-1â³-phosphate phosphatase; ARTD; ADP-ribosylt
Nanopharmaceuticals for wound healing - Lost in translation?
Keywords: Nanomaterials; Biomaterials; Advanced wound healing therapies; Current regulatory perspective; ASTM; American Society for Testing and Materials; CQA; critical quality attributes; ECM; extracellular matrix; EGF; epidermal growth factor; EMA; European medic
Variable-focus microscopy and UV surface dissolution imaging as complementary techniques in intrinsic dissolution rate determination
Keywords: IBU; ibuprofen; USP; United Sates Pharmacopeia; SDS; sodium dodecyl sulphate; DSC; differential scanning calorimetry; XRPD; x-ray powder diffraction; IDR; intrinsic dissolution rate; SDI; surface dissolution imaging; API; active pharmaceutical ingredient;
Testing of a palatable bait and compatible vaccine carrier for the oral vaccination of European badgers (Meles meles) against tuberculosis
Keywords: HPO; hydrogenated (hardened) peanut oil; QC; quality control; PT; paste-bait; EP; European pharmacopoeia; USP; United States pharmacopoeia; IPA; iophenoxic acid; TAMC; total aerobic microbial count; TYMC; total yeast and mould count; Badger; BCG; Oral vac
USP15 attenuates IGF-I signaling by antagonizing Nedd4-induced IRS-2 ubiquitination
Keywords: Insulin-like growth factor (IGF); Insulin receptor substrate (IRS)-2; Ubiquitin-specific protease 15 (USP15); Nedd4; Ubiquitination; IGF; insulin-like growth factor; IRS; insulin receptor substrate; PI3K; phosphatidylinositol 3-kinase; USP; ubiquitin-spec
Characterization of the radiosynthesis and purification of [18F]THK-5351, a PET ligand for neurofibrillary tau
Keywords: Alzheimer's disease; Positron emission tomography; THK; Radiochemistry; Formulation; Automation; USP; Radiochemical stability;
Ovarian tumor domain-containing protein 1 deubiquitinates and stabilizes p53
Keywords: Mdm2; mouse double minute 2 homolog; RING; really interesting new gene; DUB; deubiquitinase; USP; ubiquitin-specific protease; OTU; ovarian tumor proteases; OTUD1; ovarian tumor domain-containing protein 1; UIM; ubiquitin interacting motif; PI; propidium
Parent heparin and daughter LMW heparin correlation analysis using LC-MS and NMR
Keywords: Low molecular weight heparin; Parent heparin; Liquid chromatography mass spectrometry; Nuclear magnetic resonance; Correlation; LMWH; Low Molecular Weight Heparin; OSCS; Over-sulfated chondroitin sulfate; USP; United States Pharmacopeia; PNNL; Pacific Nor
Histone ubiquitination in the DNA damage response
Keywords: DSB; DNA double strand breaks; HR; homologous recombination; NHEJ; non homologous end-joining; PTM; post-translational modification; DUB; deubiquitinating enzyme; USP; ubiquitin specific protease; PRC; polycomb repressive complex; RING; really interesting
The SeDeM Expert Diagram System: Its performance and predictability in direct compressible formulations containing novel excipients and different types of active ingredients
Keywords: % < 50; Particle size; %H; Hygroscopicity; %HR; Loss on drying; API; Active pharmaceutical ingredient; Carr; Carr's index; Coh; Cohesion index; Da; Bulk density; Dc; Tapped density; Haus; Hausner ratio; Ie; Inter-particle porosity; Iθ; Homogeneity inde
Possible roles of the transcription factor Nrf1 (NFE2L1) in neural homeostasis by regulating the gene expression of deubiquitinating enzymes
Keywords: Proteostasis; Ubiquitination; Deubiquitination; Neurodegeneration; Gene regulation; ARE; antioxidant response element; CNC; Cap'n'Collar; DUB; deubiquitinating enzyme; Nrf1; NF-E2-related factor 1; NFE2L1; NF-E2-like 1; qRT-PCR; quantitative real time- PC
The substrate binding domains of human SIAH E3 ubiquitin ligases are now crystal clear
Keywords: DUB; Deubiquitinase; ERAD; endoplasmic-reticulum associated degradation; ESI; electrospray ionization; HEPES; 4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid; ITC; isothermal titration calorimetry; ML; maximum-likelihood; RING; really-interesting new g
Simultaneous spectrophotometric determination of glimepiride and pioglitazone in binary mixture and combined dosage form using chemometric-assisted techniques
Keywords: C; Concentration matrix; C*; new concentration matrix; CLS; classical least-squares; CRACLS; Concentration residual augmented classical least-squares; GLM; Glimepiride; ILS; inverse least-squares; PCR; principal component regression; PIO; Pioglitazone; PL
Gamma sterilization of diclofenac sodium loaded- N-trimethyl chitosan nanoparticles for ophthalmic use
Keywords: ANOVA; analysis of variance; CFU; colony-forming unit; CV; cell viability; DC; diclofenac sodium; DC-TMCNs; diclofenac sodium loaded-N-trimethyl chitosan nanoparticles; DQ; degree of quaternization; DQEA; degree of quaternization obtained by elemental ana
RNAi suppression of nuclear receptor genes results in increased susceptibility to sulfoxaflor in brown planthopper, Nilaparvata lugens
Keywords: AHR; aryl hydrocarbon receptor; BLAST; basic local alignment search tool; CAR; constitutive androstane receptor; CYP; cytochrome P450; DBD; DNA-binding domain; ERR; estrogen-related receptor; EST; expressed sequence tag; GR; glucocorticoid receptor; HNF4;
Integrated transcriptomic and proteomic analysis of the bile stress response in probiotic Lactobacillus salivarius LI01
Keywords: LGG; Lactobacillus rhamnosus GG; DGE; digital gene expression; iTRAQ; isobaric tags for relative and absolute quantitation; RT; room temperature; RPKM; reads per kilobase of exon model per million mapped reads; DEGs; differentially expressed genes; FDR; f
USP15 stabilizes the transcription factor Nrf1 in the nucleus, promoting the proteasome gene expression
Keywords: Ubiquitination; Deubiquitination; Proteasomal degradation; Transcription factor; Gene regulation; ARE; antioxidant response element; CNC; Cap'n'Collar; DUB; deubiquitinating enzyme; ER; endoplasmic reticulum; NHB1; N-terminal homology box 1; Nrf1; NF-
Lys63/Met1-hybrid ubiquitin chains are commonly formed during the activation of innate immune signalling
Keywords: Ubiquitin; Innate immunity; TNF; TLR3; NOD1; LUBAC; AMSH-LP; AMSH-like protein; λ-PPase; bacteriophage λ protein phosphatase; BMDM; bone marrow-derived macrophages; JNK; c-Jun N-terminal kinase; cIAP; cellular Inhibitor of Apoptosis; DUB; deubiquitylase
The Evaluation of In Vitro Drug Dissolution of Commercially Available Oral Dosage Forms for Itraconazole in Gastrointestinal Simulator With Biorelevant Media
Keywords: precipitation; supersaturation; Caco-2 cells; dissolution; formulation; gastrointestinal; in vitro/in vivo correlations; intestinal absorption; permeability; cyclodextrins; AUC; area under the curve; AUDC; area under the dissolved drug amount-time curve
Steady-state kinetic studies reveal that the anti-cancer target Ubiquitin-Specific Protease 17 (USP17) is a highly efficient deubiquitinating enzyme
Keywords: Ubiquitin Specific Protease 17; DUB3; Ubiquitin; Protein refolding; USP17; Deubiquitinating; DUB; deubiquitinating enzyme; USP; Ubiquitin Specific Protease; Ub; ubiquitin; CDC25A; cell division cycle 25A; RCE1; Ras converting enzyme 1; IPTG; isopropyl β-
Soignants d'unités de soins palliatifs confrontés à une demande d'euthanasie : étude qualitative pilote
Keywords: Soins palliatifs; USP; Demandes d'euthanasie; Vécu des soignants; Palliative care; Palliative care unit; Euthanasia request; Caregivers' experiences;
Regulation of peroxisomal matrix protein import by ubiquitination
Keywords: AAA; ATPase associated with diverse cellular activities; APEM9; aberrant peroxisome morphology 9; HECT; homologous to the E6-AP carboxyl-terminus; PTS; peroxisomal targeting sequence; RBR ligase; RING-between-RING ligase; RING; really interesting new gene
Establishment of chondroitin B lyase-based analytical methods for sensitive and quantitative detection of dermatan sulfate in heparin
Keywords: ChonB; chondroitin B lyase; CP; Chinese Pharmacopoeia; CS; chondroitin sulfate; DS; dermatan sulfate; E.coli; Escherishchia coli; EP; European Pharmacopoeia; GAG; glycosaminoglycan; GalNAc4S; 4-O-sulfo-α-d-N-acetylgalactosamine; GlcNS6S; 6-O-sulfo-N-sulf
Characterization of the interaction between the dopamine D4 receptor, KLHL12 and β-arrestins
Keywords: GPCR; β-arrestin; KLHL12; ubiquitination; dopamine D4 receptor; β2AR; β2-adrenergic receptor; ADHD; attention deficit hyperactivity disorder; BTB; bric à brac 1, tramtrack, and broad-complex; co-IP; co-immunoprecipitation; CXCR4; C-X-C chemokine recep
Carrier-free high-dose dry powder inhaler formulation of ibuprofen: Physicochemical characterization and in vitro aerodynamic performance
Keywords: Ibuprofen (PubChem CID: 3672); Tween 20 (PubChem CID: 443314); sodium dodecyl sulfate (PubChem CID: 3423265); IBU; ibuprofen; GI; gastrointestinal; SEM; scanning electron microscopy; SSA; specific surface area; FT-IR; Fourier transform infrared spectrosco
HPAEC-PAD quantification of Haemophilus influenzae type b polysaccharide in upstream and downstream samples
Keywords: CPS; capsular polysaccharide; DSP; downstream processing; ESTD; external standard; Glc; glucose; Glc-6-P; d-glucose-6-phosphate; Hib; Haemophilus influenzae type b; HPAEC-PAD; high performance anion exchange chromatography with pulsed amperometric detecti
Calendering as a direct shaping tool for the continuous production of fixed-dose combination products via co-extrusion
Keywords: Calendering; Co-extrusion; Continuous production; Fixed-dose combination product; Sustained release; Immediate release; HME; hot-melt extrusion; FDC; fixed-dose combination; MPT; metoprolol tartrate; HCT; hydrochlorothiazide; EC; ethylcellulose; PEO; poly
TRANSVAC research infrastructure - Results and lessons learned from the European network of vaccine research and development
Keywords: Vaccine; Research and Development; European Research Infrastructures; Services; Standardisation; Harmonisation; Animal Models; Adjuvants; Biomarkers; FP7; AIDS; Acquired immunodeficiency syndrome; BCG; Mucobacterium bovis bacille calmette-guérin; DTH;
Structural and functional analysis of two universal stress proteins YdaA and YnaF from Salmonella typhimurium: possible roles in microbial stress tolerance
Keywords: USP; Universal Stress Protein; ATP; adenosine triphosphate; RMSD; root mean square deviation; Universal stress proteins; ATPase; Chloride ion binding; Zinc binding; Fatty acid metabolism;