کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8644398 | 1569759 | 2018 | 31 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Characterization of the Ubiquitin Specific Protease (USP) family members in the fast and slow muscle fibers from Chinese perch (Siniperca chuatsi)
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کلمات کلیدی
USPMAFbxMuRF1Ubiquitin specific proteaseSiniperca chuatsi - Sinperca chuatsimuscle RING finger 1 - انگشت رینگ عضلانی 1Muscle degradation - تخریب عضلاتKEGG یا Kyoto Encyclopedia of Genes and Genomes - دایرة المعارف ژن ها و ژنوم کیوتو Kyoto Encyclopedia of Genes and Genomes - دایره المعارف ژنتیک ژن ها و ژنوم کیوتوCyld - سیلدSkeletal muscle - عضله اسکلتیGene ontology - هستیشناسی ژنی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
ژنتیک
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Skeletal muscle atrophy results from fasting, disuse and other systemic diseases. Muscle atrophy is associated with increased muscle protein degradation via the Ubiquitin proteasome system (UPS). The Ubiquitin Specific Proteases (USPs), also known as deubiquitinating enzymes, regulates a wide variety of cellular processes in skeletal muscle. In our study, among the 41 members of the USP family identified in the skeletal muscle transcriptome of Chinese perch, 24 USPs were differentially expressed between the fast and slow muscle fibers. The expressional profile of 4 muscle-related USPs (USP10, USP14, USP19, USP45) was investigated in the fast and slow muscle in response to fasting at 4 and 7â¯days. The results showed that the expression of USP10, USP14 and USP19 was significantly increased in the fast muscle after fasting for 4â¯days and 7â¯days. But only the USP10 and USP14 had significantly increased at 7â¯days of fasting in the slow muscle. The expression of MAFbx and MuRF1 up-regulated and major myofibrillar genes down-regulated, indicating that all of these four USPs are involved in the protein degradation of the fast and slow muscle.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Gene - Volume 677, 30 November 2018, Pages 1-9
Journal: Gene - Volume 677, 30 November 2018, Pages 1-9
نویسندگان
FangLiang Zhang, YuLong Li, Lin Chen, Jia Cheng, Ping Wu, WuYing Chu, JianShe Zhang,