A putative role for endogenous FGF-2 in FGF-1 mediated differentiation of human preadipocytes

► FGF-1 reduces expression and secretion of FGF-2 in human preadipocytes. ► FGF-2 siRNA reduces proliferation/increases early expression of adipogenic markers. ► FGF-1 induced decrease in FGF-2 contributes to FGF-1's adipogenic effects.