کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8477865 1550934 2011 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Behavioral insights from mouse models of forebrain- and amygdala-specific glucocorticoid receptor genetic disruption
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیولوژی سلول
پیش نمایش صفحه اول مقاله
Behavioral insights from mouse models of forebrain- and amygdala-specific glucocorticoid receptor genetic disruption
چکیده انگلیسی
Genetic modulation of glucocorticoid receptor (GR) function in the brain using transgenic and gene knockout mice has yielded important insights into many aspects of GR effects on behavior and neuroendocrine responses, but significant limitations regarding interpretation of region-specific and temporal requirements remain. Here, we summarize the behavioral phenotype associated with two knockout mouse models to define the role of GRs specifically within the forebrain and amygdala. We report that forebrain-specific GR knockout mice exhibit impaired negative feedback regulation of the hypothalamic-pituitary-adrenal (HPA) axis and increased despair- and anxiety-like behaviors. In addition, mice with a disruption of GR specifically within the central nucleus of the amygdala (CeA) are deficient in conditioned fear behavior. Overall, these models serve as beneficial tools to better understand the biology of GR signaling in the normal stress response and in mood disorders.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Molecular and Cellular Endocrinology - Volume 336, Issues 1–2, 10 April 2011, Pages 2-5
نویسندگان
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