کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8477917 | 1550934 | 2011 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Effects of dehydroepiandrosterone on proliferation and differentiation of chromaffin progenitor cells
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کلمات کلیدی
BMP4DHEA(S)phenylethanolamine N-methyl transferaseLIFPNMTEGFNGFdehydroepiandrosteroneMTSDEXbFGFDBH3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium - 3- (4،5-dimethylthiazol-2-yl) -5- (3-carboxymethoxyphenyl) -2- (4-sulfophenyl) -2H-tetrazoliumddC - DDCDMEM/F12 - DMEM / F12dopa decarboxylase - dopa dearboxylasetyrosine hydroxylase - تیروزین هیدروکسیلازdopamine β-hydroxylase - دوپامین β-هیدروکسیلازRetinoic acid - رتینوئیک اسیدepidermal growth factor - عامل رشد اپیدرمیleukemia inhibitory factor - عامل مهارکننده لوکمیAdrenal gland - غدد فوق کلیوی، غدههای آدرنالnerve growth factor - فاکتور رشد عصبbasic fibroblast growth factor - فاکتور رشد فیبروبلاست پایهHPLC - کروماتوگرافی مایعی کاراhigh-performance liquid chromatography - کروماتوگرافی مایعی کارا
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
بیولوژی سلول
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Effects of dehydroepiandrosterone on proliferation and differentiation of chromaffin progenitor cells Effects of dehydroepiandrosterone on proliferation and differentiation of chromaffin progenitor cells](/preview/png/8477917.png)
چکیده انگلیسی
Dehydroepiandrosterone producing adrenocortical zona reticularis and the adrenal medulla are in direct contact and are highly intermingled in many species. This results in potentially strong paracrine influences of high local dehydroepiandrosterone concentrations on the adrenal medulla. Dehydroepiandrosterone has neuroprotective properties and increases neural stem cell proliferation and neurogenesis. Therefore, we aimed to establish its effects on chromaffin progenitor cell proliferation and differentiation. Previously, we successfully isolated chromaffin progenitors from bovine adrenal medulla in spherical cultures, so-called chromospheres. Seven days treatment of chromospheres with dehydroepiandrosterone at high concentrations (100 μM) hampered proliferation of chromaffin progenitors. Under differentiation conditions, dehydroepiandrosterone in the presence of retinoic acid, increased tyrosine hydroxylase and decreased dopamine-β-hydroxylase mRNA expression. In addition, there was a tendency to increase dopamine contents. Dehydroepiandrosterone/retinoic acid is therefore suggested to induce dopaminergic differentiation from chromaffin progenitor cells. Furthermore, the high dehydroepiandrosterone concentrations present in the fetal and adult adrenal may play an important role in adrenomedullary cell proliferation and differentiation.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Molecular and Cellular Endocrinology - Volume 336, Issues 1â2, 10 April 2011, Pages 141-148
Journal: Molecular and Cellular Endocrinology - Volume 336, Issues 1â2, 10 April 2011, Pages 141-148
نویسندگان
Kuei-Fang Chung, Nan Qin, Andreas Androutsellis-Theotokis, Stefan R. Bornstein, Monika Ehrhart-Bornstein,