Neuroprotection by the soy isoflavone, genistein, via inhibition of mitochondria-dependent apoptosis pathways and reactive oxygen induced-NF-κB activation in a cerebral ischemia mouse model

► We investigate the neuroprotection of genistein in a cerebral ischemia mouse model. ► Genistein exerts neuroprotective and anti-oxidative effect in transient focal ischemia. ► Genistein pretreatment prevents the neuron damage through mitochondria-dependent apoptosis pathway. ► Genistein suppresses ROS-dependent NF-κB activation.