کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8480259 1551375 2015 18 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Non-coding functions of alternative pre-mRNA splicing in development
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیولوژی سلول
پیش نمایش صفحه اول مقاله
Non-coding functions of alternative pre-mRNA splicing in development
چکیده انگلیسی
A majority of messenger RNA precursors (pre-mRNAs) in the higher eukaryotes undergo alternative splicing to generate more than one mature product. By targeting the open reading frame region this process increases diversity of protein isoforms beyond the nominal coding capacity of the genome. However, alternative splicing also frequently controls output levels and spatiotemporal features of cellular and organismal gene expression programs. Here we discuss how these non-coding functions of alternative splicing contribute to development through regulation of mRNA stability, translational efficiency and cellular localization.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Seminars in Cell & Developmental Biology - Volumes 47–48, December 2015, Pages 32-39
نویسندگان
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