کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8480277 | 1551375 | 2015 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Wnt/Ã-catenin signalling and the dynamics of fate decisions in early mouse embryos and embryonic stem (ES) cells
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
بیولوژی سلول
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Wnt/Ã-catenin signalling and the dynamics of fate decisions in early mouse embryos and embryonic stem (ES) cells Wnt/Ã-catenin signalling and the dynamics of fate decisions in early mouse embryos and embryonic stem (ES) cells](/preview/png/8480277.png)
چکیده انگلیسی
Wnt/Ã-catenin signalling is a widespread cell signalling pathway with multiple roles during vertebrate development. In mouse embryonic stem (mES) cells, there is a dual role for Ã-catenin: it promotes differentiation when activated as part of the Wnt/Ã-catenin signalling pathway, and promotes stable pluripotency independently of signalling. Although mES cells resemble the preimplantation epiblast progenitors, the first requirement for Wnt/Ã-catenin signalling during mouse development has been reported at implantation [1], [2]. The relationship between Ã-catenin and pluripotency and that of mES cells with epiblast progenitors suggests that Ã-catenin might have a functional role during preimplantation development. Here we summarize the expression and function of Wnt/Ã-catenin signalling elements during the early stages of mouse development and consider the reasons why the requirement in ES cells do not reflect the embryo.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Seminars in Cell & Developmental Biology - Volumes 47â48, December 2015, Pages 101-109
Journal: Seminars in Cell & Developmental Biology - Volumes 47â48, December 2015, Pages 101-109
نویسندگان
Silvia Muñoz-Descalzo, Anna-Katerina Hadjantonakis, Alfonso Martinez Arias,