کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8480303 1551377 2015 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Molecular events and signalling pathways of male germ cell differentiation in mouse
ترجمه فارسی عنوان
حوادث مولکولی و مسیرهای سیگنالینگ تمایز سلول های بنیادی نر در موش
کلمات کلیدی
سلول های زاینده گناد جنینی، تفکیک، مایوس، دستگیری متیوتی، نیروی انسانی، ماوس،
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیولوژی سلول
چکیده انگلیسی
Germ cells, the precursors of gametes, represent a unique cell lineage that is able to differentiate into spermatozoa or oocytes depending on the chromosomal sex of the organism. In the mammalian embryonic gonad, commitment to oogenesis involves pre-meiotic DNA replication and entry into the first meiotic division; whereas, commitment to spermatogenesis involves inhibition of meiotic initiation, suppression of pluripotency, mitotic arrest and expression of specific markers that will control the development of the male germ cells. The crucial decision made by the germ line to commit to either a male or a female fate has been partially explained by genetic and ex vivo studies in mice which have implicated a complex network of regulatory genes, numerous factors and pathways. Besides the reproductive failure that may follow a deregulation of this complex network, the germ cells may, in view of their proliferative and pluripotent nature, act as precursors of potential malignant transformation and as putative targets for exogenous environmental compounds. Our review summarizes and discusses recent developments that have improved our understanding on how germ cell precursors are committed to a male or a female cell fate in the mouse gonad.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Seminars in Cell & Developmental Biology - Volume 45, September 2015, Pages 84-93
نویسندگان
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