کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8480388 1551381 2015 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
BDCA3+CLEC9A+ human dendritic cell function and development
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیولوژی سلول
پیش نمایش صفحه اول مقاله
BDCA3+CLEC9A+ human dendritic cell function and development
چکیده انگلیسی
Dendritic cells (DC) are the most potent antigen presenting cells (APC). They comprise a family of different subsets and play an essential role in the induction and regulation of immune responses. Recently, gene expression profiling identified BDCA3+CLEC9A+ DC as a separate human DC subset. This subset was identified in blood, where they represent the smallest population of human DC, as well as in lymphoid and peripheral tissues. This review summarizes the phenotypic, functional and developmental characteristics of BDCA3+CLEC9A+ DC in relation to their mouse equivalents CD8α+ DC and CD103+ DC and other human DC subsets. Apart from being potent antigen presenting cells, their specialized functional capacities compared to other human DC subsets, indicate that these BDCA3+CLEC9A+ DC are of major importance in the induction of anti-viral and anti-tumor immunity. Further characterization of their functional properties, developmental pathways and underlying molecular mechanisms may identify target molecules to fully exploit the immune modulatory function of BDCA3+CLEC9A+ DC and potential use of these cells in immunotherapy.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Seminars in Cell & Developmental Biology - Volume 41, May 2015, Pages 39-48
نویسندگان
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