کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8480402 | 1551381 | 2015 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Glycan regulation of ER-associated degradation through compartmentalization
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
VIP36ERQCPNGaseUDP-glucose:glycoprotein glucosyltransferaseGIIPeptide:N-glycanaseBAP31UGGTER exit sitesSmooth ERERGICRERCrtERADCNx - CNXER associated degradation - ER مربوط به تخریبMAMs - MAM هاN-glycosylation - N-گلیکوزیلتSER - برای بودنendoplasmic reticulum - شبکه آندوپلاسمی mannosidase - مانوسیدازHerp - هرپcalreticulin - کلرتی کولینcalnexin - کلنکسینER quality control - کنترل کیفیت ER
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
بیولوژی سلول
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Glycan regulation of ER-associated degradation through compartmentalization Glycan regulation of ER-associated degradation through compartmentalization](/preview/png/8480402.png)
چکیده انگلیسی
The internal environment of the eukaryotic cell is divided by membranes into various organelles, containing diverse functional subcompartments, which allow complex cellular life. The quality control of newly made secretory proteins relies on the ability of the endoplasmic reticulum (ER) to segregate and compartmentalize molecules at different folding states. These folding states are communicated by N-glycans present on most secretory proteins. In ER-associated degradation (ERAD), protein molecules that have been identified as terminally misfolded are sent for degradation at the cytosolic proteasomes after being dislocated from the ER to the cytosol. This review will focus on how misfolded glycoprotein molecules are segregated from their properly folded counterparts and targeted to ERAD. The pathway involves compartmentalization, which is intimately linked to differential N-glycan processing. Recent data suggests that these processes are very dynamic, and include transient assembly of ERAD machinery complexes.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Seminars in Cell & Developmental Biology - Volume 41, May 2015, Pages 99-109
Journal: Seminars in Cell & Developmental Biology - Volume 41, May 2015, Pages 99-109
نویسندگان
Ron Benyair, Navit Ogen-Shtern, Gerardo Z. Lederkremer,