کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8485149 | 1551698 | 2018 | 37 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Inhibiting HLA-G restores IFN-γ and TNF-α producing T cell in pleural Tuberculosis
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کلمات کلیدی
KirILTHLA-Gadenosine deaminase - آدنوزین دآمینازHuman leukocyte antigen-G - آنتی ژن لوسکسی انسان- Ginterleukin - اینترلوکینimmunoglobulin-like transcript - رونویسی مشابه ایمونوگلوبولینPro-inflammatory cytokines - سیتوکینهای پروتئین التهابیADA - وجود داردkiller cell immunoglobulin-like receptor - گیرنده ایمونوگلوبولین مشابه سلول قاتل
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
میکروبیولوژی و بیوتکنولوژی کاربردی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Inhibiting HLA-G restores IFN-γ and TNF-α producing T cell in pleural Tuberculosis Inhibiting HLA-G restores IFN-γ and TNF-α producing T cell in pleural Tuberculosis](/preview/png/8485149.png)
چکیده انگلیسی
Human Leukocyte Antigen-G (HLA-G), a non-classical, class Ib molecule, has been shown to mediate immunoregulatory functions by inducing apoptosis, inhibits cytotoxicity and differentiation by modulating cytokine secretion. Due to its immune-suppressive function, it facilitates tolerance in feto-maternal interface and transplantation. In contrary, it favours immune evasion of microbes and tumors by inhibiting immune and inflammatory responses. In Tuberculosis (TB), we previously reported differential expression of HLA-G and its receptor Ig-like transcript â2 (ILT-2) in disseminated vs. localized Tuberculosis. The present study explores the impact of HLA-G inhibition on the function of T cells and monocytes, in TB Pleural Effusion (PE), a localized form of TB. Blocking of HLA-G resulted in significant increase in IFN-γ and TNF-α production by CD3+ T cells. Additionally, we observed that HLA-G influences the apoptosis and cytotoxic effect of T cells from TB- PE patients. Next, we checked the impact of interaction between HLA-G and ILT-4 receptor in monocytes derived from TB-PE patients upon blocking and observed significant increase in IFN-γ production. The present study reveals for the first time HLA-G mediated suppression of Th1 cytokines, especially, IFN-γ and TNF-α in TB-PE patients.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Tuberculosis - Volume 109, March 2018, Pages 69-79
Journal: Tuberculosis - Volume 109, March 2018, Pages 69-79
نویسندگان
Abhinav Saurabh, Sushmita Chakraborty, Prabin Kumar, Anant Mohan, Anuj K. Bhatnagar, Narayan Rishi, Dipendra Kumar Mitra,