کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8497697 | 1553547 | 2018 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Adjuvant effect in aquaculture fish of cell-wall glycolipids isolated from acid-fast bacteria
ترجمه فارسی عنوان
اثر ادجوانت در ماهی های آبزی پروری از گلیکولایپید های دیواره سلولی جدا شده از باکتری های اسید سریع
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شناسی تکاملی
چکیده انگلیسی
Mycobacteriosis and nocardiosis in cultured fish caused by infections with acid-fast bacteria, are responsible for large economic losses globally. In this study, we suggest a novel adjuvant using glycolipids that activates host immune systems. The immune response to glycolipids stimulation was investigated using ginbuna crucian carp. Ginbuna vaccinated with FKC (formalin-killed cells)Â +Â glycolipids isolated from Mycobacterium sp., upregulated inflammatory- and Th1-related cytokines, and a DTH (delayed-type hypersensitivity) response was confirmed only in ginbuna vaccinated with FKCÂ +Â glycolipids. These observations suggest that glycolipids activated host innate and cell-mediated immunity. Subsequently, we evaluated the adjuvant effect of glycolipids against amberjack nocardiosis. In a challenge test, a higher survival rate was observed in amberjack vaccinated with FKCÂ +Â glycolipids emulsified with conventional oil adjuvant than in fish vaccinated with FKCÂ +Â oil adjuvant without glycolipids. Therefore, glycolipids potentially could be used as a practical, economical and safe adjuvant for aquaculture fish.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Developmental & Comparative Immunology - Volume 85, August 2018, Pages 142-149
Journal: Developmental & Comparative Immunology - Volume 85, August 2018, Pages 142-149
نویسندگان
Megumi Matsumoto, Kyosuke Araki, Sayaka Nishimura, Hideki Kuriyama, Teruyuki Nakanishi, Kazuhiro Shiozaki, Yutaka Takeuchi, Atsushi Yamamoto,