کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8497784 | 1553550 | 2018 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Internalization of large particles by turbot (Scophthalmus maximus) IgM+ B cells mainly depends on macropinocytosis
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موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شناسی تکاملی
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چکیده انگلیسی
Increasing evidence has demonstrated support for the endocytic capacities of teleost B cells. In the present study, the ability of turbot IgM+ B cells to ingest microspheres of different sizes and the corresponding internalization pathways were investigated. The results showed that IgM+ B cells exhibited relatively high endocytic capacities for 0.5â¯Î¼m and 1â¯Î¼m latex beads, and that different mechanisms were employed for IgM+ and IgMâ cells to uptake 0.5â¯Î¼m and 1â¯Î¼m beads. For 0.5â¯Î¼m beads, IgM+ B cells apparently employed macropinocytosis-dependent endocytic pathway, whereas IgMâ cells utilized a different process involving both clathrin- and caveolae-mediated pathways. For the uptake of 1â¯Î¼m beads, IgM+ cells relied mainly on macropinocytosis and partially on caveolae-mediated pathway, while IgMâ cells utilized the routes similar to that of internalizing 0.5â¯Î¼m beads. Consistently, the internalized microspheres were co-localized with high-molecular-mass dextran in IgM+ phagocytic cells. In addition to latex beads, IgM+ B cells could also ingest inactivated bacteria predominately through macropinocytosis and caveolae-mediated endocytosis. These results collectively indicated that macropinocytosis is principally responsible for particle uptake by turbot IgM+ B cells.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Developmental & Comparative Immunology - Volume 82, May 2018, Pages 31-38
Journal: Developmental & Comparative Immunology - Volume 82, May 2018, Pages 31-38
نویسندگان
Yi-qun Li, Li Sun, Jun Li,