کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8498026 | 1553575 | 2016 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Zebrafish Plzf transcription factors enhance early type I IFN response induced by two non-enveloped RNA viruses
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شناسی تکاملی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Zebrafish Plzf transcription factors enhance early type I IFN response induced by two non-enveloped RNA viruses Zebrafish Plzf transcription factors enhance early type I IFN response induced by two non-enveloped RNA viruses](/preview/png/8498026.png)
چکیده انگلیسی
The BTB-POZ transcription factor Promyelocytic Leukemia Zinc Finger (PLZF, or ZBTB16) has been recently identified as a major factor regulating the induction of a subset of Interferon stimulated genes in human and mouse. We show that the two co-orthologues of PLZF found in zebrafish show distinct expression patterns, especially in larvae. Although zbtb16a/plzfa and zbtb16b/plzfb are not modulated by IFN produced during viral infection, their over-expression increases the level of the early type I IFN response, at a critical phase in the race between the virus and the host response. The effect of Plzfb on IFN induction was also detectable after cell infection by different non-enveloped RNA viruses, but not after infection by the rhabdovirus SVCV. Our findings indicate that plzf implication in the regulation of type I IFN responses is conserved across vertebrates, but at multiple levels of the pathway and through different mechanisms.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Developmental & Comparative Immunology - Volume 57, April 2016, Pages 48-56
Journal: Developmental & Comparative Immunology - Volume 57, April 2016, Pages 48-56
نویسندگان
E. Aleksejeva, A. Houel, V. Briolat, J.-P. Levraud, C. Langevin, P. Boudinot,