کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8498151 | 1553593 | 2018 | 27 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
14-3-3β/α-A interacts with glycoprotein of spring viremia of carp virus and positively affects viral entry
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موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
علوم آبزیان
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: 14-3-3β/α-A interacts with glycoprotein of spring viremia of carp virus and positively affects viral entry 14-3-3β/α-A interacts with glycoprotein of spring viremia of carp virus and positively affects viral entry](/preview/png/8498151.png)
چکیده انگلیسی
Spring viremia of carp virus (SVCV) is a fierce pathogen causing high mortality in the common carp. The glycoprotein (G protein) of SVCV is a pivotal component of the viral structure, located in the surface of the virion, and plays a key role in viral endocytosis. In this study, tandem affinity purification (TAP) followed by mass spectrometry analysis (LC-MS/MS) was carried out to search for novel host molecules that interact with SVCV G protein and a 14-3-3β/α-A protein was identified. The level of 14-3-3β/α-A mRNA expression was dramatically down regulated by SVCV infection. Furthermore, over expression of 14-3-3β/α-A results in a significantly increased SVCV attachment and entry in FHM cells. This study reveals an important role of 14-3-3 protein in regulating the early stage of SVCV infection, which offers a potential target for development of anti-SVCV therapies.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Fish & Shellfish Immunology - Volume 81, October 2018, Pages 438-444
Journal: Fish & Shellfish Immunology - Volume 81, October 2018, Pages 438-444
نویسندگان
Buxin Chen, Chen Li, Yeda Wang, Yuanan Lu, Fang Wang, Xueqin Liu,