کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8500688 | 1553759 | 2015 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
A Novel Inherited Cerebellar Abiotrophy in a Cohort of Related Goats
ترجمه فارسی عنوان
یک رمان مرغ دریایی آبیوتروفی در گروهی از بز های مرتبط
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کلمات کلیدی
مدل حیوانی، آبیوتروفی مخچه آتاکسی مخچه بز
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
علوم دامی و جانورشناسی
چکیده انگلیسی
Cerebellar abiotrophies, also known as cerebellar ataxias, are characterized by premature post-natal degeneration of cerebellar neurons. This report describes the clinical, magnetic resonance imaging (MRI), gross, histopathological and immunohistochemical features of a novel inherited cerebellar abiotrophy in a cohort of three closely related mixed-breed goats (Capra aegagrus hircus) in the southeastern USA. The animals all presented with early juvenile-onset ataxia, hypermetria, wide-based stance, head tremors and nystagmus. On MRI and at gross examination, there was moderate thinning of the cerebellar vermis and sharpening of the folia. Histologically, the vermis, paravermis and flocculonodular lobe had moderate to severe segmental loss of Purkinje cells with sparing of the hemispheres and secondary loss of granule cells and astrogliosis. Heritable cerebellar ataxias have been reported in many domestic animal species, but not, to the authors' knowledge, as a heritable condition in goats.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Comparative Pathology - Volume 153, Issues 2â3, AugustâOctober 2015, Pages 135-139
Journal: Journal of Comparative Pathology - Volume 153, Issues 2â3, AugustâOctober 2015, Pages 135-139
نویسندگان
J.W. Koehler, B.W. Newcomer, M. Holland, J.M. Caldwell,