کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8504306 | 1554333 | 2018 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Pharmacokinetics and bioavailability of marbofloxacin in lambs following administration of intravenous, intramuscular and subcutaneous
ترجمه فارسی عنوان
فارماکوکینتیک و قابلیت دسترسی بیولوژیک مارکوفلوکساسین در بره ها پس از تزریق داخل وریدی، عضلانی و زیر جلدی
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کلمات کلیدی
فلوروکینولون ها، ماربوفلوکساسین، فارماکوکینتیک، گوشت بره،
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
علوم دامی و جانورشناسی
چکیده انگلیسی
In this study, the pharmacokinetic disposition and bioavailability of marbofloxacin (MB) were determined in lambs after single intravenous (IV), intramuscular (IM), and subcutaneous (SC) administrations at a dose of 3â¯mg/kg. The plasma concentration of MB was measured using high-performance liquid chromatography-UV, and the pharmacokinetic parameters were analyzed using a non-compartmental analysis. Following IV, IM, and SC administrations, the mean terminal half-life (t1/2Êz) was 11.48, 12.64, and 24.86â¯h, respectively, and the mean residence time (MRT) was 7.27, 7.81, and 10.11â¯h, respectively. The bioavailability (F) was 96.01 and 126.39%, after IM and SC administration, respectively. This study showed that SC administration of MB at a dose of 3â¯mg/kg exhibited flip-flop pharmacokinetics in lambs. These results suggested that MB could be useful in the treatment of severe systemic infections, such as those with M. haemolytica (MICâ¯=â¯0.035â¯Î¼g/mL), in lambs since high AUC0-24/MIC and Cmax/MIC ratios were achieved after IV and IM administration at 3â¯mg/kg. However, MB administration (3â¯mg/kg) via the IV, IM, and SC routes might not be effective in the treatment of respiratory infections caused by organisms with MIC90 value in lambs.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Small Ruminant Research - Volume 159, February 2018, Pages 5-10
Journal: Small Ruminant Research - Volume 159, February 2018, Pages 5-10
نویسندگان
Feray Altan, Orhan Corum, Duygu Durna Corum, Orkun Atik, Kamil Uney,