Pharmacokinetics, biodistribution, and bioavailability of gossypol-loaded Pluronic® F127 nanoparticles

Gossypol, gossypol-loaded Pluronic® F127 nanoparticles (GLPFNs) for intravenous (i.v.) administration were prepared and its pharmacokinetic and biodistribution studies were performed. The bioavailability of GLPFNs was enhanced by threefold after encapsulation, and higher uptake in RES organs was observed after i.v. administration of GLPFNs than gossypol alone.204