کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8517361 | 1556587 | 2018 | 29 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Disease-modifying benefit of Fyn blockade persists after washout in mouse Alzheimer's model
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب رفتاری
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Disease-modifying benefit of Fyn blockade persists after washout in mouse Alzheimer's model Disease-modifying benefit of Fyn blockade persists after washout in mouse Alzheimer's model](/preview/png/8517361.png)
چکیده انگلیسی
Alzheimer's disease remains without a disease-modifying therapy that improves symptoms after therapy withdrawal. Because no investigational agents have demonstrated disease-modifying effects clinically, we tested whether the Fyn inhibitor, saracatinib, provides persistent improvement in a transgenic model. Aged APPswe/PS1ÎE9 mice were treated with saracatinib or memantine for 4 weeks and spatial memory improved to control levels. After drug washout, there was sustained rescue of both memory function and synapse density by saracatinib, but a loss of benefit from memantine. These data demonstrate a disease-modifying persistent benefit for saracatinib in a preclinincal Alzheimer's model, and distinguish its action from that of memantine.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuropharmacology - Volume 130, 1 March 2018, Pages 54-61
Journal: Neuropharmacology - Volume 130, 1 March 2018, Pages 54-61
نویسندگان
Levi M. Smith, Rong Zhu, Stephen M. Strittmatter,