کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8528918 | 1558846 | 2018 | 25 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The role of verapamil and SL-327 in morphine- and ethanol-induced state-dependent and cross state-dependent memory
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب سلولی و مولکولی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: The role of verapamil and SL-327 in morphine- and ethanol-induced state-dependent and cross state-dependent memory The role of verapamil and SL-327 in morphine- and ethanol-induced state-dependent and cross state-dependent memory](/preview/png/8528918.png)
چکیده انگلیسی
Our results show that amnestic effects of morphine (10.0â¯mg/kg, s.c.) and ethanol (1.0â¯g/kg, i.p.) can be reversed by pre-test administrations of morphine (10.0â¯mg/kg, s.c.), ethanol (1.0â¯g/kg, i.p.) and nicotine (0.1â¯mg/kg, s.c.), indicating morphine and ethanol SDM, as well as morphine-ethanol, morphine-nicotine, ethanol-morphine and ethanol-nicotine cross SDM. Pre-test co-treatment of verapamil (10.0â¯mg/kg, i.p.) with morphine/ethanol/nicotine increased all investigated SDM and cross SDM effects. Pre-test co-treatment of SL-327 (10.0â¯mg/kg, i.p.) diminished morphine- and ethanol-induced SDM along with the cross effects except ethanol-morphine cross SDM. In conclusion, SDM depends on ERK1/2 activation and also verapamil affects this type of memory, although the exact mechanism of its cognitive action has not been investigated in this study.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Pharmacology - Volume 834, 5 September 2018, Pages 318-326
Journal: European Journal of Pharmacology - Volume 834, 5 September 2018, Pages 318-326
نویسندگان
Agnieszka Michalak, Karolina Pekala, Barbara Budzynska, Marta Kruk-Slomka, Grazyna Biala,