(19αH)-lupane and (9βH)-lanostane triterpenes from Euphorbia helioscopia trigger apoptosis of tumor cell

Seven new triterpenes named euphorbatrine A-G (1-7), including two (19αH)-lupane (1-2) and three (9βH)-lanostane (4-6) were isolated from E. helioscopia. 5 and 6 increased Hela −/− cell death via activating apoptosis pathway other than necroptosis, with EC50 values of 1.59 ± 0.25 and 26.48 ± 0.78 μM, respectively.56