Preparation and evaluation of sodium CMC zaltoprofen spherical agglomerates for direct compression

Zaltoprofen spherical agglomerates were prepared by spherical crystallization technique using a three solvent system comprising a good solvent (acetone), a bad solvent (water) and a bridging liquid (dichloromethane) by using a hydrophilic polymer sodium CMC in different concentrations for enhancing micromeritic properties and dissolution rate. The prepared zaltoprofen spherical agglomerates were evaluated in terms of flow properties, particle size analysis, compression and dissolution behavior. Physical characters of the crystals were studied for the morphology of crystals using scanning electron microscope (SEM), identification of polymorphism done by X-ray powder diffraction (XPRD) and for thermo dynamic properties using differential scanning colorimetry (DSC). The prepared agglomerates were improved the micromeritic properties, packability, wettability, solubility and compaction behavior, as well as dissolution behavior in comparison to pure zaltoprofen drug.