Synthesis and in silico drug likeness evaluation of N,5-disubstituted-1,3-thiazolidine-2,4-dione analogues

A series of N,5-disubstituted-1,3-thiazolidine-2,4-dione analogues (3a-h, 4a-h) were prepared by knoevenagel condensation of various aromatic aldehydes with N-substituted-1,3-thiazolidine-2,4-diones in toluene. The structures of the synthesized compounds were established based on the IR, 1H NMR, Mass and elemental analysis data. Drug likeness of the synthesized molecules were evaluated using online Molinspiration web JME Editor and OSIRIS Property Explorer and were found to obey rule of thumb.