Aqueous extract of Baccharis trimera improves redox status and decreases the severity of alcoholic hepatotoxicity

Hepatotoxicity induced by ethanol and the interference of Baccharis trimera aqueous extract (AQ) in this process. When HepG2 cells were incubated with ethanol there were increase of ROS, NO and transcriptional factor Nrf2. B. trimera decreased ROS and NO, and stimulated Nrf2. In in vivo experiment ethanol promoted increased in creatinin, total cholesterol, fraction non HDL, reduced/oxidized glutathione ratio, TBARS, protein carbonylated and MMP-2 activity, and decreased GPx activity. B. trimera promoted a decreased in reduced/oxidized glutathione ratio, TBARS and MMP-2 activity, besides increased in GPx activity. The livers became steatotic, but B. trimera aqueous extract decreased the degree of damaged.