کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8545954 | 1561685 | 2018 | 39 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Urinary phthalate metabolite concentrations in girls with premature thelarche
ترجمه فارسی عنوان
غلظت متابولیت فتالات ادرار در دختران مبتلا به نارسایی قلبی
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کلمات کلیدی
تلارکه زودرس، فتالات دی-(2-اتیل هگزیل) فتالات، مونو (2-اتیل هگزیل) فتالات،
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم محیط زیست
بهداشت، سم شناسی و جهش زایی
چکیده انگلیسی
In girls, breast development before eight years of age is called “premature thelarche (PT)”. There are few studies in literature that show the interaction between PT and phthalate exposure. The aim of this study was to determine the urinary levels of di-(2-ethylhexyl) phthalate (DEHP) metabolites and other phthalate metabolites in girls with PT. PT group consisted of 29 newly diagnosed subjects. Control group comprised of healthy age-matched girls (nâ¯=â¯25). Urinary phthalate metabolite concentrations were measured by liquid chromatography/tandem mass spectroscopy (LC-MS/MS). The urinary concentrations of mono-(2-ethyl-hexyl)phthalate (MEHP) in the PT group (33.96â¯Â±â¯6.88â¯Î¼g/g creatinine) were found to be significantly higher compared to control group (11.54â¯Â±â¯1.39â¯Î¼g/g creatinine, pâ¯=â¯0.002). In PT group, %MEHP was also markedly higher vs. control (17.84â¯Â±â¯3.31 vs. 6.44â¯Â±â¯1.13, pâ¯=â¯0.001). Our results suggest that DEHP is more efficiently converted to MEHP in girls with PT, the importance of which needs to be further elucidated.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Environmental Toxicology and Pharmacology - Volume 59, April 2018, Pages 172-181
Journal: Environmental Toxicology and Pharmacology - Volume 59, April 2018, Pages 172-181
نویسندگان
Erdem Durmaz, Pinar Erkekoglu, Ali Asci, Sema Akçurin, İffet Bircan, Belma Kocer-Gumusel,