کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8546097 | 1561688 | 2017 | 17 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Identification of key genes and pathways and therapeutic agents in cadmium-treated liver cells: A bioinformatics study
ترجمه فارسی عنوان
شناسایی ژن ها و مسیرهای کلیدی و عوامل درمانی در سلول های کبدی تحت درمان با کادمیم: یک مطالعه بیوانفورماتیک
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کلمات کلیدی
Ier3GEOFOSL1ITGA2EGR1Connectivity mappingDEGsCMAPendothelin-1 - اندوتلین-1KEGG یا Kyoto Encyclopedia of Genes and Genomes - دایرة المعارف ژن ها و ژنوم کیوتو Kyoto Encyclopedia of Genes and Genomes - دایره المعارف ژنتیک ژن ها و ژنوم کیوتوLiver cells - سلولهای کبدیGene ontology - هستیشناسی ژنیearly growth response 1 - پاسخ رشد اولیه 1Gene Expression Omnibus - ژن بیان OmnibusDifferentially expressed genes - ژن های متفاوت بیان شده استCadmium - کادمیم
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم محیط زیست
بهداشت، سم شناسی و جهش زایی
چکیده انگلیسی
Evidence indicates that Cadmium (Cd) can accumulate in liver, which results in acute or chronic cell damage with unclear complex mechanisms. Thus, we aimed to explore the possible molecules and pathways by using bioinformatics methods Consequently, two datasets (GSE8865 and GSE31286) were retrieved and the differentially expressed genes (DEGs) were screened out. The intersection of the DEGs included seven up-regulated and forty-three down-regulated genes, which were mainly enriched in biological cell proliferation items, and were enriched in several metabolism-related pathways. Among the DEGs, several hub genes such as EGR1, FOSL1, ITGA2, EDN1, and IER3 were screened out through protein-protein interaction analysis. Interestingly, BW-B70C was predicted to be a potential agent for attenuating Cd-induced liver cell damage. The present study gave a novel insight into the mechanisms of Cd-induced liver cell damage or malignant transformation and identified several small agents that might be critical for Cd toxicity prevention and treatment.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Environmental Toxicology and Pharmacology - Volume 56, December 2017, Pages 145-150
Journal: Environmental Toxicology and Pharmacology - Volume 56, December 2017, Pages 145-150
نویسندگان
Liang Zhang, Yi Huang, Zhen Yu, Mengmeng Shao, Yunbo Luo, Yi Zhu,