کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8546208 1561697 2016 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Effect of exposure to staphylococcus aureus, particulate matter, and their combination on the neurobehavioral function of mice
ترجمه فارسی عنوان
اثر قرار گرفتن در معرض استافیلوکوک اورئوس، ذرات و ترکیب آنها بر عملکرد عصبی رفتاری موش
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم محیط زیست بهداشت، سم شناسی و جهش زایی
چکیده انگلیسی
Neurotoxicity in Kunming mice caused by Staphylococcus aureus (S. aureus) and Particulate matter (PM) as individual matter and mixtures was studied in this paper. Male Kunming mice were instilled intratracheally with PM at doses of 0.2 mg/mouse and S. aureus at doses of 5.08 × 106 CFU/mouse as individual matter and mixtures two times at 5-day intervals. Morris water maze (MWM) test was performed during the exposure experiment. One day following the exposure experiment, the expression of neurotrophins, neurotransmitters, cholinergic system enzymes, oxidative damage levels, and pro-inflammatory cytokines (TNF-α, IL-1β) in the brain of mice were determined. Combined treatment of PM and S. aureus led to significant increment of escape latency at day 6, 8, and 10. Oxidative stress levels, and pro-inflammatory cytokines were affected significantly by S. aureus and PM as individual matter and mixtures. Meanwhile, Glu contents were increased significantly in S. aureus group, ChAT levels were decreased significantly in PM group, combined treatment of PM and S. aureus led to significant concentration reduction of AChE. Treatment of S. aureus or PM- S. aureus combination also led to significant concentration reduction of BDNF. Results showed that combined treatment of PM and S. aureus induced damage on physique and motor function, as well as impairment on learning and memory capacity of mice. Oxidative damage, abnormal metabolism of neurotransmitters and cholinergic system enzymes, and the alternation of neurotrophins and pro-inflammatory cytokines expression might be the possible mechanisms for PM − S. aureus −induced neurotoxicity.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Environmental Toxicology and Pharmacology - Volume 47, October 2016, Pages 175-181
نویسندگان
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