کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8546878 | 1561727 | 2018 | 24 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Maternal dietary nitrate intake and risk of neural tube defects: A systematic review and dose-response meta-analysis
ترجمه فارسی عنوان
دریافت نیترات در رژیم غذایی مادر و ریسک نقص لوله عصبی: یک بررسی متداول و متاآنالیز دوز پاسخ
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کلمات کلیدی
متاآنالیز، نیترات، نقص لوله عصبی، بررسی سیستماتیک،
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
دانش تغذیه
چکیده انگلیسی
Despite growing evidence for the potential teratogenicity of nitrate, knowledge about the dose-response relationship of dietary nitrate intake and risk of specific birth defects such as neural tube defects (NTDs) is limited. Therefore, the aim of this meta-analysis was to synthesize the knowledge about the dose-response relation between maternal dietary nitrate intake and the risk of NTDs. We conducted a systematic search in PubMed, ISI Web of Science and Scopus up to February 2018 for observational studies. Risk ratios (RRs) and 95% confidence intervals (95% CI) were calculated using a random-effects model for highest versus lowest intake categories. The linear and non-linear relationships between nitrate intake and risk of NTDs were also investigated. Overall, 5 studies were included in the meta-analyses. No association was observed between nitrate intake and NTDs risk in high versus low intake (RR: 1.33; 95% CI: 0.89-1.99, pâ¯=â¯0.158) and linear dose-response (RR: 1.03; 95% CI: 0.99-1.07, pâ¯=â¯0.141) meta-analysis. However, there were positive relationships between nitrate intake and risk of NTDs in non-linear (pnon-linearity<0.05) model. Findings from this dose-response meta-analysis indicate that maternal nitrate intake higher than â¼3â¯mg/day is positively associated with NTDs risk.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Food and Chemical Toxicology - Volume 118, August 2018, Pages 287-293
Journal: Food and Chemical Toxicology - Volume 118, August 2018, Pages 287-293
نویسندگان
Nader Rahimi Kakavandi, Amin Hasanvand, Mahmoud Ghazi-Khansari, Ahmad Habibian Sezavar, Hassan Nabizadeh, Mohammad Parohan,