کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8547161 | 1561727 | 2018 | 36 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The ameliorative effects of boron against acrylamide-induced oxidative stress, inflammatory response, and metabolic changes in rats
ترجمه فارسی عنوان
اثرات مخرب بور در برابر استرس اکسیداتیو ناشی از آکریل آمید، پاسخ التهابی و تغییرات متابولیکی در موش صحرایی
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کلمات کلیدی
آکریلامید، بور، استرس اکسیداتیو، بیان ژن، هیستوپاتولوژی، موش
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
دانش تغذیه
چکیده انگلیسی
Acrylamide (ACR) is a hazardous substance associated with the accumulation of excessive reactive oxygen species and causes oxidative stress. Presence of ACR in foods leads to public health concerns due to its known neurotoxic, genotoxic, and carcinogenic effects. The present study investigated the ameliorative effects of boron (B) against ACR exposed rats. Forty Wistar albino male rats, fed with low-boron diet, were randomly and equally allocated into 5 groups. The control group was orally treated with physiological saline as placebo, the second group was orally given 15â¯mg/kg ACR. The other groups were orally treated with 15â¯mg/kg ACR and B at the levels of 5, 10, and 20â¯mg/kg/day for 60 days, respectively. ACR-treatment significantly increased malondialdehyde levels whereas decreased glutathione levels in rat tissues. Also, ACR-treatment increased the activities of superoxide dismutase and catalase in erythrocytes and tissues. Meanwhile, mRNA expression levels of NFĸB, IFN-γ, IL-1β, and TNF-α in liver and brain of rats were increased under ACR treatment. Additionally, ACR caused a significant decrease in the level of high-density lipoprotein, with increase in the levels of low-density lipoprotein, triglyceride, cholesterol, glucose, urea nitrogen, and creatinine. Lastly, B alleviated histopathological alterations induced by ACR in rat tissues.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Food and Chemical Toxicology - Volume 118, August 2018, Pages 745-752
Journal: Food and Chemical Toxicology - Volume 118, August 2018, Pages 745-752
نویسندگان
Ulas Acaroz, Sinan Ince, Damla Arslan-Acaroz, Zeki Gurler, Ismail Kucukkurt, Hasan Hüseyin Demirel, Halil Ozancan Arslan, Nuray Varol, Kui Zhu,