کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8550514 | 1562037 | 2016 | 33 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
In vitro evaluation of pyrethroid-mediated changes on neuronal burst parameters using microelectrode arrays
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موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم محیط زیست
بهداشت، سم شناسی و جهش زایی
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چکیده انگلیسی
Effects of pyrethroids (beta-cyfluthrin, bifenthrin, cypermethrin, deltamethrin, lambda-cyhalothrin, and permethrin) on the burst parameters (mean burst rate [MBR], percent spikes in burst [PSB], mean burst duration [MBD], mean spikes in burst [MSB], mean interspike interval in burst [MISIB], and mean interburst interval [MIBI]) have been investigated using the microelectrode array technique. Rat cortical neuronal networks (between 24 and 35 DIV) were exposed to the five accumulative concentrations of pyrethroids (0.01 μM, 0.1 μM, 1 μM, 10 μM, and 100 μM) after initially recording the baseline activity. When compared to the baseline, the burst parameter that had undergone the most change (either increase/decrease) at the initial concentrations was MBR, followed by MIBI and PSB. The other burst parameters (MSB, MBD, and MISIB) did not undergo much change (either increase/decrease) by the pyrethroids at the initial concentrations when compared to the baseline. The MBR of all pyrethroids rose at initial concentrations followed by decrease at higher concentrations. A drop in the MIBI accompanied the rise in the MBR. The rank orders of relative potency of pyrethroids on the IC50 of different burst parameters clearly distinguish type-1 pyrethroids (bifenthrin, permethrin) from the type-2 pyrethroids (beta-cyfluthrin, cypermethrin, deltamethrin, lambda-cyhalothrin), with type-2 being more potent. The rank order of relative potency of pyrethroids based on the IC50 of MBR was beta-cyfluthrin > lambda-cyhalothrin > deltamethrin > cypermethrin > bifenthrin > permethrin.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: NeuroToxicology - Volume 57, December 2016, Pages 270-281
Journal: NeuroToxicology - Volume 57, December 2016, Pages 270-281
نویسندگان
Mohana Krishnan Baskar, Prakhya Balakrishna Murthy,