کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8599232 | 1565433 | 2017 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Potencial regenerativo do tecido cartilaginoso por célulasâtronco mesenquimais: atualização, limitações e desafios
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موضوعات مرتبط
علوم پزشکی و سلامت
پرستاری و مشاغل بهداشتی
درمان فیزیکی و توانبخشی
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چکیده انگلیسی
Advances in the studies with adult mesenchymal stem cells (MSCs) have turned the tissue regenerative therapy into a promising tool in many areas of medicine. In orthopedics, one of the main challenges has been the regeneration of cartilage tissue, mainly in diarthroses. In the induction of the MSCs, in addition to cytodifferentiation, the microenvironmental context of the tissue to be regenerated and an appropriate spatial arrangement are extremely important factors. Furthermore, it is known that MSCs differentiation is fundamentally determined by mechanisms such as cell proliferation (mitosis), biochemicalâmolecular interactions, movement, cell adhesion, and apoptosis. Although the use of MSCs for the cartilage regeneration remains at a research level, there are important questions to be resolved in order to make this therapy efficient and safe. It is known, for instance, that the expansion of chondrocytes in cultivation, needed to increase the number of cells, could end up producing fibrocartilage instead of hyaline cartilage. However, the latest results are promising. In 2014, the first stage I/II clinical trial to evaluate the efficacy and safety of the intraâarticular injection of MSCs in femorotibial cartilage regeneration was published, indicating a decrease in injured areas. One issue to be explored is how many modifications in the articulate inflammatory environment could induce differentiation of MSCs already allocated in that region. Such issue arose from studies that suggested that the suppression of the inflammation may increase the efficiency of tissue regeneration. Considering the complexity of the events related to the chondrogenesis and cartilage repair, it can be concluded that the road ahead is still long, and that further studies are needed.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Revista Brasileira de Ortopedia - Volume 52, Issue 1, JanuaryâFebruary 2017, Pages 2-10
Journal: Revista Brasileira de Ortopedia - Volume 52, Issue 1, JanuaryâFebruary 2017, Pages 2-10
نویسندگان
Ivana Beatrice Mânica da Cruz, Antônio Lourenço Severo, Verônica Farina Azzolin, Luiz Filipe Machado Garcia, André Kuhn, Osvandré Lech,