کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8611502 | 1567220 | 2017 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Efeitos de dexmedetomidina perineural no nervo ciático em ratos
ترجمه فارسی عنوان
اثرات دگزمودومیدین پرینورال بر روی عصب سیتوپاتیک در موش صحرایی
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کلمات کلیدی
تست تأخیر از دست کشیدن پا متراکم عصب سیاتیک، الکترومیوگرافی، دگزامتامینید، تست تاخیر خروج پنجه پا، متراکم عصب سیاتیک، الکترومیوگرافی، دگزامتامینید،
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
بیهوشی و پزشکی درد
چکیده انگلیسی
The present study was designed to test the hypothesis that high dose dexmedetomidine would increase the duration of antinociception to a thermal stimulus in a rat model of sciatic nerve blockade without causing nerve damage. The rats were anesthetized with isoflurane. After electromyography (EMG) recordings, right sciatic nerves were explored and perineural injections were delivered: Group D (n = 7), 40 μg μg kgâ1 dexmedetomidine administration, Group II (n = 6), (0.2 mL) saline administration, Group III (n = 2), only surgically exploration of the right sciatic nevre. Time to paw withdrawal latency (PAW) to a thermal stimulus for both paws and an assessment of motor function were measured every 30 min after the nerve block until a return to baseline. The compound muscle action potential (CMAP) of right and left sciatic nerves were recorded 10 times per each nerve once more after perineural injections at 14 day. After EMG recordings, right and the part of left sciatic nerve were excised at a length of at minimum 15 mm for histopathological examination. Comparison of right/left CMAP amplitude ratios before and 14 days after the procedure showed a statistically significant difference (p = 0.000). There were no differences in perineural inflammation between the Group D, Group S, and Group E at 14 days.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Brazilian Journal of Anesthesiology - Volume 67, Issue 1, JanuaryâFebruary 2017, Pages 57-66
Journal: Brazilian Journal of Anesthesiology - Volume 67, Issue 1, JanuaryâFebruary 2017, Pages 57-66
نویسندگان
Abdulkadir YektaÅ, Murat Ãabalar, Mehmet Sar, AyÅin Alagöl, Duygu Sultan Ãelik, Vildan Yayla, Deniz Tolga,