کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8628923 1568706 2018 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Multiple sclerosis genetics: Results from meta-analyses of candidate-gene association studies
ترجمه فارسی عنوان
ژنتیک مولکولی اسکلروز: نتایج متاآنالیز مطالعات ارتباط نامزدی ژن
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی علوم غدد
چکیده انگلیسی
As a complex disease, multiple sclerosis (MS) susceptibility implicates many genetic and environmental factors. Usually, individual genetic association studies have several limitations, and results are specific to the population of study. The Meta-analysis approach has been proposed to resolve these limitations and to increase the power of statistical analyses. In this review, we summarize results from meta-analyses of candidate genes of MS. Using the keywords: multiple sclerosis, genetic polymorphism and meta-analysis, we searched electronic databases (PubMed, Embase and Web of Sciences) for published meta-analyses until May 2017. Meta-analyses confirmed the association of polymorphisms in fifteen candidate genes with MS disease. However, polymorphisms in fourteen genes showed none significant association. Results outlined the importance of confirmed genes to understand signaling pathways in MS disease and shed light on their utility to develop new drugs targets.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cytokine - Volume 106, June 2018, Pages 154-164
نویسندگان
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