کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8631659 | 1568943 | 2018 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Short children born small for gestational age outcomes in the era of growth hormone therapy
ترجمه فارسی عنوان
کودکان کوتاه مدت در دوران هورمون رشد در دوران بارداری کوچک می شوند
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کلمات کلیدی
rhGHIUGRCUGSilver-Russell syndromeDOHaDIGFBP-3CHDSRSSGASDSIgf1 - IGF1standard deviation - انحراف معیارcoronary heart disease - بیماری عروق کرونر قلبSmall for gestational age - حاملگی در سنین پائینDevelopmental origins of health and disease - ریشه های رشد سلامت و بیماریinsulin-like growth factor 1 - فاکتور رشد مانند انسولین 1intrauterine growth restriction - محدودیت رشد داخل رحمیStandard deviation score - نمره استاندارد انحرافGrowth hormone - هورمون رشدRecombinant human growth hormone - هورمون رشد انسانی انسانInsulin-like growth factor binding protein 3 - پروتئین اتصال دهنده فاکتور رشد مانند انسولین 3small-for-gestational-age - کوچک برای بارداری سن
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
علوم غدد
چکیده انگلیسی
Small-for-gestational age (SGA) infants are at risk for short and long term medical and metabolic complications. Most SGA infants (85-90%) demonstrate spontaneous catch-up growth, typically in the first year after birth. Although catch-up growth (CUG) is a desired goal, it is important to note if CUG is too rapid the infants are at increased risk for insulin resistance and type 2 diabetes mellitus as they become adults. On the flip side, infants who do not exhibit CUG are also at increased risk of adverse adult outcomes including those for cardiovascular disease, insulin resistance and type 2 diabetes mellitus, neurodevelopmental and cognitive impairments, in addition to adult short stature. Treatment with growth hormone is safe and effective not only in increasing adult height, but also in improving body composition and decreasing metabolic complications. The aims of this review are to summarize the current knowledge on what constitutes “healthy” catch-up growth in children born SGA as well as provide an update on the role of growth hormone treatment for short children born SGA.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Growth Hormone & IGF Research - Volume 38, February 2018, Pages 8-13
Journal: Growth Hormone & IGF Research - Volume 38, February 2018, Pages 8-13
نویسندگان
Santina A. Zanelli, Alan D. Rogol,