کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8633381 | 1569056 | 2017 | 43 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The hemoglobin derived peptide LVV-hemorphin-7 evokes behavioral effects mediated by oxytocin receptors
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کلمات کلیدی
GMPIRAPATSi.v.FSTACE 2i.p.EPMACEGAPDHAT4cDNA - cDNADNA - DNA یا اسید دزوکسی ریبونوکلئیکAtosiban - آتوسیبانForced swimming test - آزمون اجباری شناangiotensin converting enzyme - آنزیم تبدیل آنژیوتانسینangiotensin IV - آنژیوتانسین IVangiotensin converting enzyme 2 - آنژیوتانسین تبدیل آنزیم 2desoxyribonucleic acid - اسید desoxyribonucleicElectrocardiography - الکتروکاردیوگرافی یا قلبنگاریECG - الکتروکاردیوگرام یا نوار قلبelevated plus maze - بالا به همراه پیچ و خمintraperitoneal - داخل صفاقیIntravenous - داخل وریدیHeart rate - ضربان قلبBlood pressure - فشارخونglyceraldehyde 3-phosphate dehydrogenase - گلیسرولیدید 3-فسفات دهیدروژناز
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
علوم غدد
پیش نمایش صفحه اول مقاله

چکیده انگلیسی
LVV-hemorphin-7 (LVV-h7) is bioactive peptide resulting from degradation of hemoglobin β-globin chain. LVV-h7 is a specific agonist of angiotensin IV receptor. This receptor belongs to the class of insulin-regulated aminopeptidases (IRAP), which displays oxytocinase activity. Herein, our aims were to assess whether: i) LVV-h7 modifies centrally organized behavior and cardiovascular responses to stress and ii) mechanisms underlying LVV-h7 effects involve activation of oxytocin (OT) receptors, probably as result of reduction of IRAP proteolytic activity upon OT. Adult male Wistar rats (270-370 g) received (i.p.) injections of LVV-h7 (153 nmol/kg), or vehicle (0.1 ml). Different protocols were used: i) open field (OP) test for locomotor/exploratory activities; ii) Elevated Plus Maze (EPM) for anxiety-like behavior; iii) forced swimming test (FST) test for depression-like behavior and iv) air jet for cardiovascular reactivity to acute stress exposure. Diazepam (2 mg/kg) and imipramine (15 mg/kg) were used as positive control for EPM and FST, respectively. The antagonist of OT receptors (OTr), atosiban (1 and 0,1 mg/kg), was used to determine the involvement of oxytocinergic paths. We found that LVV-h7: i) increased the number of entries and the time spent in open arms of the maze, an indicative of anxiolysis; ii) provoked antidepressant effect in the FS test; and iii) increased the exploration and locomotion; iv) did not change the cardiovascular reactivity and neuroendocrine responses to acute stress. Also, increases in locomotion and the antidepressant effects evoked by LVV-h7 were reverted by OTr antagonist. We conclude that LVV-h7 modulates behavior, displays antidepressant and anxiolytic effects that are mediated in part by oxytocin receptors.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuropeptides - Volume 66, December 2017, Pages 59-68
Journal: Neuropeptides - Volume 66, December 2017, Pages 59-68
نویسندگان
Kellen Rosa da Cruz, Larissa Córdova Turones, Gabriel Camargo-Silva, Karina Pereira Gomes, Michelle Mendanha Mendonça, Pablinny Galdino, Christielly Rodrigues-Silva, Robson Augusto Souza Santos, Elson Alves Costa, Paulo Cesar Ghedini, Danielle Ianzer,