کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8645916 | 1569795 | 2018 | 26 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
TRPM8 activation improves energy expenditure in skeletal muscle and exercise endurance in mice
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کلمات کلیدی
DMEMAmtBHFDPGC1αTRPM8Dulbecco's modified Eagle's medium - Medal of Eagle اصلاح شده DulbeccoUcp1 - UCP1Exercise endurance - استقامت ورزشGene regulation - تنظیم ژنhigh-fat diet - رژیم غذایی با چربی بالاnormal diet - رژیم معمولیSkeletal muscle - عضله اسکلتیtransient receptor potential melastatin 8 - مولتی استاتین بالقوه گیرنده گذرا 8Energy expenditure - هزینه انرژیuncoupling protein 1 - پروتئین جدا سازی 1Intracellular calcium - کلسیم داخل سلولیPeroxisome proliferator-activated receptor-γ coactivator 1α - گیرنده پروتئینزاسیون فعال پرولاکتین-γ 1α
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
ژنتیک
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: TRPM8 activation improves energy expenditure in skeletal muscle and exercise endurance in mice TRPM8 activation improves energy expenditure in skeletal muscle and exercise endurance in mice](/preview/png/8645916.png)
چکیده انگلیسی
Skeletal muscle serving as the major organ is responsible for energy expenditure and exercise endurance, which directly influence cardiometabolic risk factors. Transient receptor potential melastatin 8 (TRPM8), a Ca2 +-permeable non-selective cation channel, plays vital roles in the regulation of various cellular functions. It has been reported that TRPM8 activation enhanced the energy metabolism of adipocytes. However, the involvement of TRPM8 in the energy metabolism of skeletal muscle remains unexplored. Our data revealed that TRPM8 was expressed in cultured C2C12 myocytes. Menthol treatment increased uncoupling protein 1 (UCP1) and peroxisome proliferator-activated receptor-γ coactivator 1α (PGC1α) expression in C2C12 myotubes through TRPM8 activation. Moreover, dietary menthol upregulated the expression of UCP1 and PGC1α in skeletal muscle of mice. In addition, dietary menthol enhanced exercise endurance and reduced blood lactic acid and triglycerides through TRPM8 activation. It is concluded that dietary menthol improves energy metabolism and exercise endurance by increasing UCP1 and PGC1α in skeletal muscles, suggesting dietary menthol might be a novel therapeutic approach for cardiometabolic diseases management and prevention.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Gene - Volume 641, 30 January 2018, Pages 111-116
Journal: Gene - Volume 641, 30 January 2018, Pages 111-116
نویسندگان
Chen Li, Jia Li, Xiujuan Xiong, Ying Liu, Yanxia Lv, Shanshan Qin, Dandan Liu, Ronghua Wei, Xuzhi Ruan, Jingxuan Zhang, Liang Xu, Xuanbin Wang, Jicheng Chen, Yonghong Zhang, Lanlan Zheng,