کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8645971 | 1569795 | 2018 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Regulation of lipid metabolism in adipose depots of fat-tailed and thin-tailed lambs during negative and positive energy balances
ترجمه فارسی عنوان
مقررات متابولیسم لیپید در انبارهای چربی از بزهای چربی و نخی در طی توازن انرژی منفی و مثبت
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کلمات کلیدی
FABP4LPLNEFAAcAcstearoyl-CoA desaturasePPIAACLYATP citrate lyaseHSLYWHAZpeptidylprolyl isomerase APPARγSREBF1GAPDHCNCPSTMRSCDSterol regulatory element-binding transcription factor 1cDNA - cDNAComplementary DNA - DNA تکمیلیacetyl-CoA carboxylase - استیل کروکسی سیلازnon-esterified fatty acids - اسیدهای چرب غیر استرادیدهGene expression - بیان ژنNEL - درCornell Net Carbohydrate and Protein System - سیستم کربوهیدرات و پروتئین Cornell NetTranscription factors - عوامل رونویسیhormone sensitive lipase - لیپاز حساس به هورمونLipoprotein lipase - لیپو پروتئین لیپازLipogenesis - لیپوژنزfatty acid binding protein 4 - پروتئین اتصال دهنده اسید چرب 4threshold cycle - چرخه آستانهtotal mixed ration - کل جیره مخلوط شدهglyceraldehyde 3-phosphate dehydrogenase - گلیسرولیدید 3-فسفات دهیدروژنازPeroxisome proliferator activated receptor gamma - گیرنده گیرنده فعال فعال پروکسیزوم فعال است
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
ژنتیک
چکیده انگلیسی
This study aimed to evaluate the effects of negative and positive energy balances on gene expression of regulators and enzymes controlling lipogenesis and lipolysis in muscle and adipose depots of fat-tailed and thin-tailed lambs. Lambs were slaughtered during neutral, negative and positive energy balances for sample collection. Real time q-PCR was conducted to measure the gene expression. Expression of PPARγ was increased in response to positive energy balance regardless of genotype and type of tissue (P < 0.04). Expression of SREBF1 was reduced in response to negative and positive energy balances in fat-tailed lambs, whereas in thin-tailed lambs, downregulated SREBF1 was restored during positive energy balance (P < 0.01). Enhancement in FABP4 expression in response to negative and positive energy balances was respectively higher in thin-tailed and fat-tailed lambs affected by interaction of genotype and energy balance (P < 0.11). In thin-tailed lambs, the enhanced FABP4 expression in response to negative energy balance was considerably higher in mesenteric adipose depot, whereas in fat-tailed lambs, positive energy balance induced enhancement in FABP4 expression was considerably higher in fat-tail adipose depot. The results demonstrate that transcription regulation of lipogenesis and lipolysis during negative and positive energy balances occurs differently in fat-tailed and thin-tailed lambs. Thin-tailed and fat-tailed lambs are respectively more responsive to negative and positive energy balances and mesenteric and fat-tail adipose depots respectively in thin-tailed and fat-tailed lambs are the main adipose depots responsible for higher responsiveness of thin-tailed and fat-tailed lambs to negative and positive energy balances.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Gene - Volume 641, 30 January 2018, Pages 203-211
Journal: Gene - Volume 641, 30 January 2018, Pages 203-211
نویسندگان
Hossein Zakariapour Bahnamiri, Abolfazl Zali, Mahdi Ganjkhanlou, Mostafa Sadeghi, Hossein Moradi Shahrbabak,