کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8651185 | 1572057 | 2018 | 26 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Markers of Reperfusion and Long-Term (8-Year) Prognosis after Primary Percutaneous Coronary Intervention
ترجمه فارسی عنوان
نشانگرهای رپرفیوژن و پیش آگهی طولانی مدت (8 ساله) پس از مداخله کرونری اولیه پوستی
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موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
کاردیولوژی و پزشکی قلب و عروق
چکیده انگلیسی
Thrombolysis in Myocardial Infarction (TIMI) flow, myocardial perfusion grade (MPG), and infarct size are established markers of reperfusion in patients with ST-segment elevation myocardial infarction. Whether these markers provide long-term prognostic information remains unknown. This study included 1,406 patients with ST-segment elevation myocardial infarction who underwent primary percutaneous coronary intervention. Postreperfusion TIMI flow, MPG, and infarct size (evaluated by scintigraphy at 7 to 14 days) were measured. The primary outcome was 8-year mortality. Overall there were 190 deaths. The Kaplan-Meier estimates of mortality were 22.6% (37 deaths) and 16.8% (153 deaths) according to TIMI flow â¤2 and TIMI flow 3 (adjusted hazard ratio [HR] 0.82, 95% confidence interval [CI] 0.66 to 1.00, pâ=â0.058 for 1 grade increment), 21.6% (106 deaths) and 14.5% (84 deaths) according to MPG â¤2 and MPG 3 (adjusted HR 0.87 [0.77 to 0.98], pâ=â0.020 for 1 grade increment) and 21.7% (115 deaths) and 13.7% (75 deaths) according to infarct size >10% (median value) and infarct size â¤10% of the left ventricle (adjusted HR 1.08 [1.03 to 1.13], pâ=â0.001, for 5% of left ventricle increment in infarct size). The C statistic of the model for all-cause mortality was 0.810 (0.781 to 0.839) with baseline variables, 0.812 (0.783 to 0.841) after incorporation of TIMI flow (P for significance compared to the model with baseline variables =â0.140), 0.813 (0.784 to 0.841) after incorporation of MPG (pâ=â0.345) and 0.815 (0.786 to 0.842) after incorporation of infarct size (pâ=â0.08). In conclusion, markers of reperfusion independently predict long-term mortality after primary percutaneous coronary intervention but offer limited incremental prognostic value to that provided by evaluation of baseline cardiovascular risk factors and clinical data.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: The American Journal of Cardiology - Volume 122, Issue 1, 1 July 2018, Pages 39-46
Journal: The American Journal of Cardiology - Volume 122, Issue 1, 1 July 2018, Pages 39-46
نویسندگان
Gjin MD, Robert A. MB, BCh, PhD, Salvatore MD, Massimiliano MD, Roisin MB, BCh, Julia MD, Karl-Ludwig MD, Heribert MD, Adnan MD,