کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8651300 | 1572061 | 2018 | 22 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Usefulness of Platelet-to-Lymphocyte Ratio to Predict Long-Term All-Cause Mortality in Patients at High Risk of Coronary Artery Disease Who Underwent Coronary Angiography
ترجمه فارسی عنوان
سودمندی نسبت پلاکت به لنفوسیتها برای پیش بینی مرگ و میر درازمدت در بیماران مبتلا به بالا بودن خطر بیماری عروق کرونری که تحت آنژیوگرافی عروق کرونر قرار گرفتند
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موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
کاردیولوژی و پزشکی قلب و عروق
چکیده انگلیسی
Platelet-to-lymphocyte ratio (PLR) has recently been studied as a biomarker in patients with established coronary artery disease (CAD). The association between PLR and long-term all-cause mortality is unclear in patients at high risk of CAD who undergo coronary angiography for various indications. Follow-up was completed for 514 patients who underwent coronary angiography in a prospective study cohort. The primary end point was all-cause mortality. Patients were classified into tertiles based on preangiography PLR and also dichotomized based on the optimal cutoff at a PLR of 137, determined from the receiver operating characteristic curve analysis. The mean follow-up period was 5.0â±â1.3 years, with 50 all-cause deaths. On the Kaplan-Meier analysis, patients in Tertile 3 (PLRâ>â145) had worse prognosis than patients in Tertiles 1 (PLRââ¤â106) and 2 (PLR 106.1 to 145) (pâ=â0.0075), and patients with PLRââ¥â137 had a significantly higher rate of all-cause mortality than those with PLRâ<â137 (pâ=â0.0006). On multivariate Cox regression adjusting for known cardiovascular risk factors, PLR was a strong, independent predictor of long-term all-cause mortality on the tertile analysis (Tertile 3 vs Tertile 1: hazard ratio 2.52, 95% confidence interval 1.18 to 5.39, pâ=â0.017) and based on the cutoff at a PLR of 137 (PLRââ¥â137 vs <137: hazard ratio 2.25, 95% confidence interval 1.21 to 4.20, pâ=â0.011). In conclusion, elevated PLR is associated with long-term all-cause mortality in patients at high risk of CAD who undergo coronary angiography, and PLR may be a useful prognostic biomarker in this population.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: The American Journal of Cardiology - Volume 121, Issue 9, 1 May 2018, Pages 1021-1026
Journal: The American Journal of Cardiology - Volume 121, Issue 9, 1 May 2018, Pages 1021-1026
نویسندگان
Yun Suk G. MD, Arul MBChB, Matthew MD, Rohullah MD, Heath MBBS, John PhD, Andrew M. MBBS, PhD,