کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8657997 | 1574859 | 2018 | 37 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Personalized Management Approach for OSA
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
aHIREMPcritDREADDs - DREADD هاSleep apnea - آپنه خوابsleep-disordered breathing - اختلال تنفسی در خوابrapid eye movement - حرکت سریع چشمSleep medicine - داروهای خوابUpper airway - راه هوایی بالاapnea/hypopnea index - شاخص آپنه / هیپوپنیcritical closing pressure - فشار بسته شدن بحرانیPhenotyping - فنوتایپینگPalm - نخلdesigner receptors exclusively activated by designer drugs - گیرنده های طراح که به طور خاص توسط داروهای طراح فعال می شوند
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
کاردیولوژی و پزشکی قلب و عروق
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Personalized Management Approach for OSA Personalized Management Approach for OSA](/preview/png/8657997.png)
چکیده انگلیسی
OSA is a heterogeneous disorder. If left untreated, it has major health, safety, and economic consequences. In addition to varying levels of impairment in pharyngeal anatomy (narrow/collapsible airway), nonanatomical “phenotypic traits” are also important contributors to OSA for most patients. However, the majority of existing therapies (eg, CPAP, oral appliances, weight loss, positional therapy, upper airway surgery) target only the anatomical cause. These are typically administered as monotherapy according to a trial and error management approach in which the majority of patients are first prescribed CPAP. Despite its high efficacy, CPAP adherence remains unacceptably low, and second-line therapies have variable and unpredictable efficacies. Recent advances in knowledge regarding the multiple causes of OSA using respiratory phenotyping techniques have identified new targets or “treatable traits” to direct therapy. Identification of the traits and development of therapies that selectively target one or more of the treatable traits has the potential to personalize the management of this chronic health condition to optimize patient outcomes according to precision medicine principles. This brief review highlights the latest developments and emerging therapies for personalized management approaches for OSA.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Chest - Volume 153, Issue 3, March 2018, Pages 744-755
Journal: Chest - Volume 153, Issue 3, March 2018, Pages 744-755
نویسندگان
Jayne C. PhD, Jason PhD, Danny J. PhD,