Effect of metformin combined with lifestyle modification versus lifestyle modification alone on proinflammatory-oxidative status in drug-naïve pre-diabetic and diabetic patients: A randomized controlled study

In both intervention groups, the relative changes in plasma TNFα were significantly correlated (P < 0.01) with systolic blood pressure and the relative changes in oxidative stress were markedly correlated (P < 0.05) with total cholesterol.