کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8663093 | 1576515 | 2017 | 17 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
An investigation on the impact of carnosine on the myocardium in lower extremity ischemia-reperfusion injury in rats
ترجمه فارسی عنوان
بررسی تأثیر کارنوزین بر روی میوکارد در آسیب های بینایی ایسکمی-رپرفیون اندام تحتانی در موش صحرایی
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موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
کاردیولوژی و پزشکی قلب و عروق
چکیده انگلیسی
The purpose of this study was to investigate the effect of carnosine (CAR) on ischemia-reperfusion (I-R) injury to the myocardium occurring after occlusion reperfusion of the infrarenal abdominal aorta (IAA) in rats. In this study, 30 Sprague-Dawley rats were randomly divided into three equal groups which are control, I-R, and I-RÂ +Â CAR groups. Laparotomy and IAA dissection were performed in all groups; occlusion was not performed in the control group. In the control group, the process was completed in 90Â min as in the other two groups. In the I-R and I-RÂ +Â CAR groups, the IAA was occluded by microvascular clamps; the first 30Â min represented the ischemia period, followed by declamping and a 60Â min reperfusion period. After the I-R period, rats were sacrificed. Heart specimens and blood samples were taken for histopathological and biochemical evaluation. Statistically significant alterations were observed in the control group in comparison with the other groups in the histopathological analyses. Although there was no significant difference between the I-R and I-RÂ +Â CAR groups regarding the histopathological findings, the I-RÂ +Â CAR group displayed more favorable histopathological findings compared with the I-R group. There were also significant alterations between the I-R and I-RÂ +Â CAR groups regarding aspartate aminotransferase (AST), creatine kinase (CK), and lactate dehydrogenase (LDH) enzyme levels. The I-RÂ +Â CAR group had significantly lower enzyme levels compared with the I-R group. In conclusion, carnosine seems to effectively prevent myocardial I-R injury in rats, as demonstrated by histopathological and biochemical evaluation.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of the Cardiovascular Academy - Volume 3, Issues 3â4, SeptemberâDecember 2017, Pages 109-113
Journal: International Journal of the Cardiovascular Academy - Volume 3, Issues 3â4, SeptemberâDecember 2017, Pages 109-113
نویسندگان
Aydin Keskin, Batur G Kanar, Rayiha G Kanar, Alper Kepez, Bulent Tunerir,