PCSK-9: papel en las hipercolesterolemias y anticuerpos monoclonales específicos inhibitorios

Evolocumab and alirocumab, monoclonal antibodies against PCSK9, are very useful novel therapeutic tools in heterozygous familial hypercholesterolemia, some homozygous familial hypercholesterolemia cases, and in individuals with a high cardiovascular risk whose LDL-C levels cannot be controlled with maximum tolerated doses of highly effective statins, ezetimibe, and lifestyle changes.