کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8680271 | 1579257 | 2018 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Tau positron emission tomography imaging in tauopathies: The added hurdle of off-target binding
ترجمه فارسی عنوان
تصویربرداری توموگرافی تیتو در تئوپاتیها: مانع اضافه شدن اتصال غیر هدف
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موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
عصب شناسی
چکیده انگلیسی
Ligands targeting tau for use with positron emission tomography have rapidly been developed during the past several years, enabling the in vivo study of tau pathology in patients with Alzheimer's disease and related non-Alzheimer's disease tauopathies. Several candidate compounds have been developed, showing good in vitro characteristics with respect to their ability to bind tau deposits; off-target binding, however, has also been observed. In this short commentary, we briefly summarize the available in vivo and in vitro evidence pertaining to their off-target binding and discuss the different approaches that are needed for the future development of tau positron emission tomography tracers.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring - Volume 10, 2018, Pages 232-236
Journal: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring - Volume 10, 2018, Pages 232-236
نویسندگان
Laetitia Lemoine, Antoine Leuzy, Konstantinos Chiotis, Elena Rodriguez-Vieitez, Agneta Nordberg,