کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8681020 | 1579503 | 2018 | 39 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Time-dependent changes in cardiorespiratory functions of anesthetized rats exposed to sustained hypoxia
ترجمه فارسی عنوان
تغییرات وابسته به زمان در عملکردهای قلب و ریه در موشهای بیهوش شده در معرض هیپوکسی پایدار است
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کلمات کلیدی
واکنش قلب و عروق، بدن کاروتید، موش هیپوکسی پایدار،
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب سلولی و مولکولی
چکیده انگلیسی
Although cardiovascular responses may be altered by respiratory changes under prolonged hypoxia, the relationship between respiratory and cardiovascular changes remains unknown. The aim of the present study is to clarify cardiorespiratory changes in anesthetized rats during and after hypoxic conditions using simultaneous recordings of cardiorespiratory variables with 20-sec recording intervals. After air breathing for 20â¯min (pre-exposure period), rats were subjected to 10% O2 for 2â¯h (hypoxic exposure period) and then air for 30â¯min (recovery period). Minute ventilation (VE), respiratory frequency, tidal volume, arterial blood pressure (BP), and heart rate (HR) were continuously monitored during the experimental period. Just after hypoxic exposure, VE, BP, and HR exhibited an overshoot, undershoot, and overshoot followed by a decrease, respectively. During the remaining hypoxic exposure period, continuous high VE and low BP were observed, whereas HR re-increased. In the recovery period, VE, BP, and HR showed an undershoot, increase, and decrease followed by an increase, respectively. These results suggest that the continuation of enhanced VE and re-increased HR, probably, due to carotid body excitation and accompanying sympathetic activation, during the late period of hypoxic exposure are protective responses to avoid worsening hypoxemia and further circulatory insufficiencies under sustained hypoxia.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Autonomic Neuroscience - Volume 212, July 2018, Pages 1-9
Journal: Autonomic Neuroscience - Volume 212, July 2018, Pages 1-9
نویسندگان
Kouki Kato, Ryosuke Morinaga, Seigo Fushuku, Nobuaki Nakamuta, Yoshio Yamamoto,