کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8681099 1579508 2017 39 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Regional cerebral cortical thickness correlates with autonomic outflow
ترجمه فارسی عنوان
ضخامت قشر منطقه ای مغزی با جریان خروجی خودبخودی ارتباط دارد
کلمات کلیدی
ضخامت قشر، انسولا، قشر پیشروی مغزی متوسط، کنترل خودمختاری،
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب سلولی و مولکولی
چکیده انگلیسی
Dysregulation of autonomic control often develops with advancing age, favoring a chronic state of heightened sympathetic outflow with parasympathetic withdrawal. However, the mechanisms of this age-related autonomic impairment are not known. This study tested the hypothesis that inter-individual differences in autonomic outflow across the adult age-span are related to cerebral cortex thickness. A total of 55 healthy, active individuals participated in this study (21-73 years; 18 female). Physical fitness was treated as a possible covariate (VO2peak: 26-81 mL/kg/min). Cardiovagal baroreflex sensitivity, heart rate variability, and muscle sympathetic nerve activity (MSNA) were assessed during a laboratory session. T1-weighted images acquired at 3 T facilitated measures of cortical thickness (Brain Voyager 2.8.4). A priori cortical regions of interest included the medial prefrontal cortex (MPFC) and insula cortex. Cortical thickness at the MPFC correlated strongly with markers of autonomic outflow including heart rate variability (ln-high frequency power (slope: − 16, r2 = 0.65), SDNN (slope: 22, r2 = 0.22), total power (slope: 2872, r2 = 0.24)), and MSNA variables (burst frequency (slope: 1, r2 = 0.16), burst incidence (slope: − 26, r2 = 0.62) and total MSNA (slope: − 847, r2 = 0.56)). Further associations with burst incidence were observed within the left insula (p < 0.05). Importantly, the strength of the relationship between autonomic variables and cortical thickness was determined by age, and was not altered following adjustments for cardiorespiratory fitness. The current results implicate cortical atrophy in the frontal lobe as a contributor to both the sympathetic and parasympathetic changes that occur with age.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Autonomic Neuroscience - Volume 207, November 2017, Pages 28-36
نویسندگان
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