کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8684076 | 1579878 | 2018 | 12 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Long-term effect of levetiracetam monotherapy on haematological parameters in children with epilepsy: A prospective study
ترجمه فارسی عنوان
اثر طولانی اثر مونوتراپی لوتیرازکتام بر پارامترهای خون در کودکان مبتلا به صرع: یک مطالعه آینده نگر
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
عصب شناسی
چکیده انگلیسی
Studies evaluating the effect of Levetiracetam (LEV) on haematological parameters in patients with epilepsy are very limited. Short-term effects on haematological parameters in children with epilepsy, at 2 and 6 months of LEV treatment, have been previously reported in the literature. Purpose of the current study was to further investigate the long-term changes on haematological parameters in children with epilepsy during LEV monotherapy. White blood cell, neutrophils, lymphocytes, monocytes, haemoglobin, haematocrit, mean corpuscular volume, mean corpuscular haemoglobin, mean corpuscular haemoglobin concentration and platelets were measured in 20 children (11 females, mean age 6,5â¯Â±â¯4,4 years, range 2-15 years) with epilepsy, before and after 12 months of LEV monotherapy. Lymphocyte count was significantly decreased at 12 months (pâ¯=â¯0.003) of LEV treatment. Three children (15%) at 12 months of treatment had lymphocyte count below 10th percentile for age. Neutrophils counts were significantly increased and platelets counts were significantly decreased at 12 months of treatment (pâ¯=â¯0.046 and pâ¯=â¯0.006, respectively). In addition, haematocrit and mean corpuscular volume were significantly increased at 12 months of treatment (pâ¯=â¯0.036 and pâ¯=â¯0.031, respectively). There were no significant alterations in the other parameters evaluated during the study. No association was found between all parameters and LEV dosage (mg/kg) at 12 months of treatment. Large, prospective studies are needed to investigate the clinical significance of the above haematological changes and whether these parameters should be monitored periodically in children taking LEV.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Epilepsy Research - Volume 145, September 2018, Pages 160-162
Journal: Epilepsy Research - Volume 145, September 2018, Pages 160-162
نویسندگان
Achilleas Attilakos, Argirios Dinopoulos, Maria Paschalidou, Maria Tsirouda, Maria Karalexi, Alexia Prasouli, Anastasia Garoufi,